Protein Alignment Dll and Nkx6-1

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_659204.1
• Gene: Nkx6-1 / 18096
• MGIID: 1206039
• Length: 365
• Species: Mus musculus
• Alignment Length: 199
• Identity: 57/199 - (28%)
• Similarity: 89/199 - (44%)
• Gaps: 23/199 - (11%)

  Fly     2 DAPDAPHTPKYMDGGNTAASVTPGINIPGKSAFVELQQHAAAGYGGIRSTYQHFGPQGGQDSGFP 66
            |....|..|  :..|....|.:|..:....|:.......:||......:.........|..:|.|
Mouse   100 DILSRPSMP--VASGAALPSASPSGSSSSSSSSASATSASAAAAAAAAAAAAAASSPAGLLAGLP 162

  Fly    67 SPRSALGYPFPP----MHQNSYSGYHLGSYAPPCA---------------SPPKDDFSISDKCED 112
            . .|:|..|.||    ...::.:...:|.|..|.|               |||..|..::.....
Mouse   163 R-FSSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQ 226

  Fly   113 SGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRS 177
            ..:.::..||: :..|..:|..|:..|.:.|::|:|||.||||.||.|||:|::|||:||||||:
Mouse   227 GSILLDKDGKR-KHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRT 290

  Fly   178 KYKK 181
            |::|
Mouse   291 KWRK 294

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	29/55 (53%)
Nkx6-1	NP_659204.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..136		7/37 (19%)
		Repressor domain. /evidence=ECO:0000250	102..269		38/170 (22%)
		Homeodomain	236..294	CDD:459649	30/58 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..365		57/199 (29%)
		Involved in DNA-binding. /evidence=ECO:0000250	307..365