DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dll and Msx1

DIOPT Version :9

Sequence 1:	NP_001137759.1	Gene:	Dll / 37973	FlyBaseID:	FBgn0000157	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_034965.2	Gene:	Msx1 / 17701	MGIID:	97168	Length:	303	Species:	Mus musculus

Alignment Length:	242	Identity:	75/242 - (30%)
Similarity:	100/242 - (41%)	Gaps:	74/242 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PGKSAFVELQQHAAAGYGGIRSTYQHFGPQGGQDSGFPSPRSALGYPFPPMHQNSYSGYHLGS-- 91
            ||....|.:....|...||   :.||.|.:.|          :||.|..|........:.:|.
Mouse    73 PGAKESVLVASEGAQAAGG---SVQHLGTRPG----------SLGAPDAPSSPRPLGHFSVGGLL 124

  Fly    92 --------------------------YAPPCA---SPPKDDFSISDKCEDSGLRVNGKGKKMRKP 127
                                      ::||.|   |||        .|.   ||   |.|..|||
Mouse   125 KLPEDALVKAESPEKLDRTPWMQSPRFSPPPARRLSPP--------ACT---LR---KHKTNRKP 175

  Fly   128 RTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKM-------MKA 185
            ||.:::.||..|.|:|::.|||::.||||.::||.||:|||||||||||:|.|::       :|.
Mouse   176 RTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKM 240

  Fly   186 AQGP-----GTNSGMPLGGGGPNPGQHSPNQMHSGELANGRFLWAAL 227
            |..|     ......||||    |...:.....|...|:|.|..|||
Mouse   241 AAKPMLPPAAFGLSFPLGG----PAAVAAAAGASLYSASGPFQRAAL 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeobox	127..180	CDD:278475	31/52 (60%)
Msx1	NP_034965.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..53
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..112		10/34 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	135..163		6/35 (17%)
		Homeobox	175..228	CDD:278475	31/52 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810