DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dll and DLX5

DIOPT Version :9

Sequence 1:	NP_001137759.1	Gene:	Dll / 37973	FlyBaseID:	FBgn0000157	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_005212.1	Gene:	DLX5 / 1749	HGNCID:	2918	Length:	289	Species:	Homo sapiens

Alignment Length:	289	Identity:	104/289 - (35%)
Similarity:	125/289 - (43%)	Gaps:	89/289 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 HFGPQGGQDSGFPSPRSAL--------------------GYPFPPMHQNSY-SGYHL--GSY--A 93
            ::.|.||...|:.||.||.                    .||.......|| |.||.  |:|  .
Human    47 YYSPTGGAPHGYCSPTSASYGKALNPYQYQYHGVNGSAGSYPAKAYADYSYASSYHQYGGAYNRV 111

  Fly    94 PPCASPPKDDFSISDKCEDSGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELA 158
            |...:.|:.:.:     |.....||||.||:|||||||||.||..|.||||:|||||||||||||
Human   112 PSATNQPEKEVT-----EPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELA 171

  Fly   159 ASLGLTQTQVKIWFQNRRSKYKKMMKAAQGPGTNSGMPLGGGGPNPGQHSPNQMHSGELANGRFL 223
            ||||||||||||||||:|||.||:||               .|..|.:|||:.  |..:|
Human   172 ASLGLTQTQVKIWFQNKRSKIKKIMK---------------NGEMPPEHSPSS--SDPMA----- 214

  Fly   224 WAALETNGTLALVHSTGGNNGGGSNS-GSPSHYLPPGHSPTPSSTPVSELSPEFPPTGLSPPTQA 287
                                   .|| .||:.:.|.|.|.:.|..|.:.     |||....|..:
Human   215 -----------------------CNSPQSPAVWEPQGSSRSLSHHPHAH-----PPTSNQSPASS 251

  Fly   288 PWDQKPHWI--------DHKPPPQMTPQP 308
            ..:....|.        .|.|||.....|
Human   252 YLENSASWYTSAASSINSHLPPPGSLQHP 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeobox	127..180	CDD:278475	46/52 (88%)
DLX5	NP_005212.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		0/1 (0%)
		DLL_N	32..118	CDD:315147	18/70 (26%)
		Homeobox	140..193	CDD:306543	46/52 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..251		20/87 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	270..289		5/11 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153141
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1416398at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40491
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24327
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X884
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	7.000