DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dll and DLX2

DIOPT Version :9

Sequence 1:NP_001137759.1 Gene:Dll / 37973 FlyBaseID:FBgn0000157 Length:347 Species:Drosophila melanogaster
Sequence 2:NP_004396.1 Gene:DLX2 / 1746 HGNCID:2915 Length:328 Species:Homo sapiens


Alignment Length:363 Identity:129/363 - (35%)
Similarity:158/363 - (43%) Gaps:123/363 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 GGNTAA---------SVTPGINIPGKSAFVELQQHAAAGYGGIRSTYQHFGPQGGQDSGFPS-PR 69
            |||:::         |.|..::....|::...|||.|.|.||..|.|.|.|....|.||..: |.
Human    38 GGNSSSSSSLHKPQESPTLPVSTATDSSYYTNQQHPAGGGGGGGSPYAHMGSYQYQASGLNNVPY 102

  Fly    70 SA-----LGYPFPPMHQNSYSGYHLGSYAPPCASPPKDDFSISDKCEDSGLR-VNGKGKKMRKPR 128
            ||     |||   .....||:.|...| :|....|.|:|.       :..:| ||||.||:||||
Human   103 SAKSSYDLGY---TAAYTSYAPYGTSS-SPANNEPEKEDL-------EPEIRIVNGKPKKVRKPR 156

  Fly   129 TIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMMKAA-----QG 188
            |||||.||..|.||||:|||||||||||||||||||||||||||||||||:|||.|:.     |.
Human   157 TIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSGEIPSEQH 221

  Fly   189 PGTNSGMP--------------------LGGGGPNPGQHSPNQMHSGELANGRFLWAALETNGTL 233
            ||.::..|                    .|||||..|                            
Human   222 PGASASPPCASPPVSAPASWDFGVPQRMAGGGGPGSG---------------------------- 258

  Fly   234 ALVHSTGGNNGGGSNSGSPSHYL---PPGHSPTPSSTPVSELSPEFPPTGLSPPTQAPWDQKPHW 295
                .:|..:.|.|.|.:.|.:|   |..|..:.|::.:...:|      |..|||         
Human   259 ----GSGAGSSGSSPSSAASAFLGNYPWYHQTSGSASHLQATAP------LLHPTQ--------- 304

  Fly   296 IDHKPPPQMTPQPPHPAATLHPQTHHHNPPPQMGGYVP 333
                     ||||.|         |||:   ..||..|
Human   305 ---------TPQPHH---------HHHH---HGGGGAP 321

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DllNP_001137759.1 Homeobox 127..180 CDD:278475 47/52 (90%)
DLX2NP_004396.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 16..81 13/42 (31%)
DLL_N 51..132 CDD:289198 28/84 (33%)
Homeobox 155..208 CDD:278475 47/52 (90%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..270 14/90 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 300..328 14/52 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165153148
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0850
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 153 1.000 Inparanoid score I4345
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1416398at2759
OrthoFinder 1 1.000 - - FOG0000655
OrthoInspector 1 1.000 - - otm40491
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24327
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.900

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