Protein Alignment Dll and Hoxd8

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_032302.2
• Gene: Hoxd8 / 15437
• MGIID: 96209
• Length: 289
• Species: Mus musculus
• Alignment Length: 263
• Identity: 64/263 - (24%)
• Similarity: 84/263 - (31%)
• Gaps: 102/263 - (38%)

  Fly    31 KSAFVELQQHAAAGYG-GIRSTYQ--HFGPQ------------GGQDSGFPSPRSALGYPFPPMH 80
            |:|.......|||..| .|..||.  ||.|:            |...:|||.     .:|.|..|
Mouse    14 KAAAAAAAAAAAAAAGEAINPTYYDCHFAPEVSGRHAAALQLYGNSAAGFPH-----AHPHPHPH 73

  Fly    81 QNSYSG-------------YHLGS--------YAPPCASPP------------------------ 100
            .:...|             :|.|:        .|||...||
Mouse    74 PSPPPGCGGGGGPGPGQDYFHAGAGSPTAAYQAAPPPPHPPPPPPPPPCGGIACHGEPAKFYGYD 138

  Fly   101 ----KDDFSISDKCE---------DSG--------LRVNGKGKKM------------RKPRTIYS 132
                :..|:...:.|         .||        |..:....:|            |:.|..||
Mouse   139 NLQRQPIFTTQQEAELVQYPDCKSSSGNIGEDPDHLNQSSSPSQMFPWMRPQAAPGRRRGRQTYS 203

  Fly   133 SLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMMK----AAQGPGTNS 193
            ..|..:|.:.|....||....|.|::.:|.||:.||||||||||.|:||...    .|..|....
Mouse   204 RFQTLELEKEFLFNPYLTRKRRIEVSHTLALTERQVKIWFQNRRMKWKKENNKDKFPASRPEAKD 268

  Fly   194 GMP 196
            |.|
Mouse   269 GDP 271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	25/55 (45%)
Hoxd8	NP_032302.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..125		14/67 (21%)
		COG5576	139..272	CDD:227863	37/133 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..184		3/21 (14%)
		Antp-type hexapeptide	183..188		1/4 (25%)
		Homeodomain	196..252	CDD:459649	25/55 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	252..289		5/20 (25%)