Protein Alignment Dll and Hhex

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_032271.1
• Gene: Hhex / 15242
• MGIID: 96086
• Length: 271
• Species: Mus musculus
• Alignment Length: 290
• Identity: 73/290 - (25%)
• Similarity: 113/290 - (38%)
• Gaps: 89/290 - (30%)

  Fly     9 TPKYMDG--GNTAASVTPGINIPG-KSAFVELQQ------------HAAAGYGGIRSTYQHFGPQ 58
            ||.|:|.  |...|:.||...:|. .|:|..|..            |.|..:....:....:||
Mouse    31 TPFYIDDILGRGPAAPTPTPTLPSPNSSFTSLVSSYRTPVYEPTPVHPAFSHHPAAALAAAYGP- 94

  Fly    59 GGQDSGFPSPRSALGYPFPPMHQNSYSGYHLGSYAPPCASP----PKDDFSISDKCEDSGLRVNG 119
                |||..|.    ||| |...|.|:  |......|...|    |.....:..:
Mouse    95 ----SGFGGPL----YPF-PRTVNDYT--HALLRHDPLGKPLLWSPFLQRPLHKR---------- 138

  Fly   120 KGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMMK 184
            ||.::|     :|:.|..:|.::|:..:||:.|||..||..|.|::.|||.||||||:|::::.:
Mouse   139 KGGQVR-----FSNDQTVELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQ 198

  Fly   185 AAQGPGTNSGMPLGG--GGPNPGQHSPNQMHSGELANGRFLWAALETNGTLALVHSTGGNNGGGS 247
              :.|.:|....|..  .....||..|::.:.|         |:|:.:..
Mouse   199 --ENPQSNKKDALDSLDTSCEQGQDLPSEQNKG---------ASLDRSQC--------------- 237

  Fly   248 NSGSPSHYLPPGHSPTPSS--TPVSELSPE 275
                         ||:|:|  .|.||:|.:
Mouse   238 -------------SPSPASQEDPDSEISED 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	24/55 (44%)
Hhex	NP_032271.1	Interaction with SOX13. /evidence=ECO:0000250|UniProtKB:Q03014	1..138		30/118 (25%)
		Required for WNT signaling induction. /evidence=ECO:0000250|UniProtKB:Q03014	138..271		43/171 (25%)
		Homeodomain	143..195	CDD:459649	24/56 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..271		17/99 (17%)