Protein Alignment Dll and NKX2-6

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_001129743.2
• Gene: NKX2-6 / 137814
• HGNCID: 32940
• Length: 301
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 78/273 - (28%)
• Similarity: 109/273 - (39%)
• Gaps: 75/273 - (27%)

  Fly    40 HAAAGYGGIRSTYQHFGPQGGQDSGFPSPRSALGYPFPPMHQNSYSGYHLGSYAPPCASPPKDDF 104
            |.|.|.||.|.......|.|..::........:|.|.|.::               .|||.....
Human    56 HNAGGGGGDRKLDGSEPPGGPCEAVLEMDAERMGEPQPGLN---------------AASPLGGGT 105

  Fly   105 SISDK-CEDSGLRVNG------KGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLG 162
            .:.:: ..:||..|.|      |.::.||||.::|..|:..|.|||::.:||:.|||..||::|.
Human   106 RVPERGVGNSGDSVRGGRSEQPKARQRRKPRVLFSQAQVLALERRFKQQRYLSAPEREHLASALQ 170

  Fly   163 LTQTQVKIWFQNRRSKYK-----KMMKAAQGPGT----------NSGMPLGGGGPN-PGQHSPNQ 211
            ||.|||||||||||.|.|     |.::.|..|.|          ..|.|..|.||. |...||
Human   171 LTSTQVKIWFQNRRYKCKRQRQDKSLELAGHPLTPRRVAVPVLVRDGKPCLGPGPGAPAFPSP-- 233

  Fly   212 MHSGELANGRFLWAALETNGTLALVHSTGGNNG-------GGSNSGSPSHYLPPGHSPTPS---- 265
                             .:..::.....||.:|       |...:|:||.  |..|:|..|
Human   234 -----------------YSAAVSPYSCYGGYSGAPYGAGYGTCYAGAPSG--PAPHTPLASAGFG 279

  Fly   266 -----STPVSELS 273
                 :||...|:
Human   280 HGGQNATPQGHLA 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	33/60 (55%)
NKX2-6	NP_001129743.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..135		20/93 (22%)
		Homeodomain	133..189	CDD:459649	32/55 (58%)