Protein Alignment Dll and Cdx2

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_031699.2
• Gene: Cdx2 / 12591
• MGIID: 88361
• Length: 311
• Species: Mus musculus
• Alignment Length: 252
• Identity: 70/252 - (27%)
• Similarity: 106/252 - (42%)
• Gaps: 58/252 - (23%)

  Fly    10 PKYMDGGN----TAASVTPGIN---IPGKSAFVELQQHAAAGYGG-IRSTYQHFGPQG------- 59
            |:|.|.|.    .||:.|..::   .||.|        ....||. :|..:..:.|.|
Mouse    35 PQYPDYGGYHVAAAAAATANLDSAQSPGPS--------WPTAYGAPLREDWNGYAPGGAAAANAV 91

  Fly    60 --GQDSGFPSPRSALGYPFPP---MHQNSYSGYHLGSYAPPCAS----------PPKDDFSISDK 109
              |.:.|  ||.:|:||..|.   .|.:.:...|..:.:|.|||          |.....:.:::
Mouse    92 AHGLNGG--SPAAAMGYSSPAEYHAHHHPHHHPHHPAASPSCASGLLQTLNLGPPGPAATAAAEQ 154

  Fly   110 CEDSGLRVNGKGKKMRKP-----------------RTIYSSLQLQQLNRRFQRTQYLALPERAEL 157
            ...||.|.| ..:.||||                 |.:|:..|..:|.:.|..::|:.:..::||
Mouse   155 LSPSGQRRN-LCEWMRKPAQQSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHFSRYITIRRKSEL 218

  Fly   158 AASLGLTQTQVKIWFQNRRSKYKKMMKAAQGPGTNSGMPLGGGGPNPGQHSPNQMHS 214
            ||:|||::.||||||||||:|.:|:.|..|..............|.|.|..|..:.|
Mouse   219 AATLGLSERQVKIWFQNRRAKERKIKKKQQQQQQQQQQQPPQPPPQPSQPQPGALRS 275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	27/72 (38%)
Cdx2	NP_031699.2	Caudal_act	13..178	CDD:461413	38/153 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..151		7/39 (18%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q99626	185..215		6/29 (21%)
		Homeodomain	187..242	CDD:459649	24/54 (44%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000250|UniProtKB:Q99626	227..241		11/13 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	239..311		9/37 (24%)
		4S motif, modulates transactivation activity and protein stability. /evidence=ECO:0000269|PubMed:16027724	281..293