Protein Alignment Dll and Nkx2-5

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_446103.2
• Gene: Nkx2-5 / 114109
• RGDID: 620520
• Length: 319
• Species: Rattus norvegicus
• Alignment Length: 360
• Identity: 93/360 - (25%)
• Similarity: 137/360 - (38%)
• Gaps: 95/360 - (26%)

  Fly     3 APDAPHTPKYMDGGNTAASVTPGINIPGKSAFVELQQHAAAGYGGIRSTYQ-------------- 53
            :|...|||         .||...:|:       |.||.:.|. |.:.:..:
  Rat     4 SPALTHTP---------FSVKDILNL-------EQQQRSLAA-GDLSARLEATLAPASCMLAAFK 51

  Fly    54 ---HFGPQGGQDSGFPSPRSALG-YPFPPMHQNSY---SGYHLGSYAPPCASPPKDDFSIS---- 107
               :.||:... .|....|:.|| .|.||....::   ..::..:|..|  .|.||..:..
  Rat    52 PEAYSGPEAAA-PGLAELRAELGPAPSPPKCSPAFPTAPTFYPRAYGDP--DPAKDPRADKKELC 113

  Fly   108 --------DKCEDSGLRVNGKGKKMRKPRTIYSSLQLQQLNRRFQRTQYLALPERAELAASLGLT 164
                    ||.|..|.. ..:.::.||||.::|..|:.:|.|||::.:||:.|||.:||:.|.||
  Rat   114 ALQKAVELDKAETDGAE-RPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLT 177

  Fly   165 QTQVKIWFQNRRSKYKKMMKAAQGPGTNSGMPLGGGGPNPGQHSPNQMHSGELANGRFLWAALET 229
            .|||||||||||.|.|:..:       :..:.|.|..|.|.:              |.....|..
  Rat   178 STQVKIWFQNRRYKCKRQRQ-------DQTLELLGPPPPPAR--------------RIAVPVLVR 221

  Fly   230 NGTLALVHSTG-------GNNGGGSNSGSPSHYLPPGHSPTPSSTPVSELSPEFP--PTGLSPPT 285
            :|...|..|..       |.|..|.|:     |..||:.....| |....:..:|  |....||.
  Rat   222 DGKPCLGDSAAYAPAYGVGLNAYGYNA-----YPYPGYGGAACS-PAYSCAAAYPAAPPAAQPPA 280

  Fly   286 QAPWDQKPHW----IDHKPPPQMTPQPPHPAATLH 316
            .|......::    ::....|.| ||.....:|||
  Rat   281 AAANSNFVNFGVGDLNTVQSPGM-PQGNSGVSTLH 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	32/55 (58%)
Nkx2-5	NP_446103.2	Homeodomain	144..194	CDD:459649	28/49 (57%)