Protein Alignment Dll and LBX1

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_006553.2
• Gene: LBX1 / 10660
• HGNCID: 16960
• Length: 281
• Species: Homo sapiens
• Alignment Length: 299
• Identity: 86/299 - (28%)
• Similarity: 115/299 - (38%)
• Gaps: 71/299 - (23%)

  Fly    41 AAAGYGGIRSTYQHFGPQGGQDSGFPSPRSALGYPFPPMHQNSYS---GYH-------------- 88
            ||.|....||...|..|....:... :|.|.......|..:.|||   ..|
Human     9 AAPGEERRRSPLDHLPPPANSNKPL-TPFSIEDILNKPSVRRSYSLCGAAHLLAAADKHAQGGLP 72

  Fly    89 ------LGSYAPPCASPPKD-------DFSISDKCED-SGLRVNGK---GKKMRKPRTIYSSLQL 136
                  |...:|.||.....       :.|:....|. .|:.:.|:   .||.||.||.:::.|:
Human    73 LAGRALLSQTSPLCALEELASKTFKGLEVSVLQAAEGRDGMTIFGQRQTPKKRRKSRTAFTNHQI 137

  Fly   137 QQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKK---MMKAAQGPGTNSGMPLG 198
            .:|.:||...:||:..:|.::|..||||..||..||||||:|.|:   .|||    ...|...||
Human   138 YELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKLKRDLEEMKA----DVESAKKLG 198

  Fly   199 GGGPNPGQHSPNQMHSGELANGRFLWAALETNGTLALVHSTGGNNGG----GSNSGSPSHYLPPG 259
            ..|         ||....||.       ||.|.     .:|.|..||    .|..|||  .||||
Human   199 PSG---------QMDIVALAE-------LEQNS-----EATAGGGGGCGRAKSRPGSP--VLPPG 240

  Fly   260 HSPTPSSTPVSELSPEFPPTGLSPPTQ-APWDQKPHWID 297
            ....|.:..: :|||..|.|.....:| ...|::...||
Human   241 APKAPGAGAL-QLSPASPLTDQPASSQDCSEDEEDEEID 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	25/55 (45%)
LBX1	NP_006553.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35		7/26 (27%)
		Homeodomain	126..182	CDD:459649	25/55 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	214..281		23/73 (32%)