DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dll and CDX4

DIOPT Version :9

Sequence 1:	NP_001137759.1	Gene:	Dll / 37973	FlyBaseID:	FBgn0000157	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_005184.1	Gene:	CDX4 / 1046	HGNCID:	1808	Length:	284	Species:	Homo sapiens

Alignment Length:	218	Identity:	63/218 - (28%)
Similarity:	97/218 - (44%)	Gaps:	29/218 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 APHTPKYMDGGNTAASVTPGINIPGKS-AFVELQQHAAAGYGGIRSTYQHFGPQGGQDSGFPSPR 69
            :|::|...|.     ||.||   |..: ..|.:....::......:.|.:.||.||..||...|.
Human    74 SPYSPPREDW-----SVYPG---PSSTMGTVPVNDVTSSPAAFCSTDYSNLGPVGGGTSGSSLPG 130

  Fly    70 SALGYPFPPMHQNSYSGYHLGSYAPPCASPPKDDFSISDKCEDSGLRVNGKGKKMRKPRTIYSSL 134
            .|.|...|           ..:.|...:||.:...|.......: ::|.||.:...|.|.:|:..
Human   131 QAGGSLVP-----------TDAGAAKASSPSRSRHSPYAWMRKT-VQVTGKTRTKEKYRVVYTDH 183

  Fly   135 QLQQLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMMKAAQGPGTNSGMPLGG 199
            |..:|.:.|...:|:.:..::|||.:|||::.||||||||||:|.:||:|.......|||..:
Human   184 QRLELEKEFHCNRYITIQRKSELAVNLGLSERQVKIWFQNRRAKERKMIKKKISQFENSGGSV-- 246

  Fly   200 GGPNPGQHSPNQMHSGELANGRF 222
                  |...:.:..|||.|..|
Human   247 ------QSDSDSISPGELPNTFF 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeobox	127..180	CDD:278475	23/52 (44%)
CDX4	NP_005184.1	Caudal_act	13..162	CDD:309740	24/106 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..155		11/45 (24%)
		Homeobox	177..229	CDD:306543	23/51 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..259		6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810