Protein Alignment Dll and CDX1

DIOPT Version :10

• Sequence 1: NP_001137759.1
• Gene: Dll / 37973
• FlyBaseID: FBgn0000157
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_001795.2
• Gene: CDX1 / 1044
• HGNCID: 1805
• Length: 265
• Species: Homo sapiens
• Alignment Length: 209
• Identity: 60/209 - (28%)
• Similarity: 85/209 - (40%)
• Gaps: 63/209 - (30%)

  Fly    50 STYQHFGPQGGQDSGFPSPRSALGYPFPPMHQNSYSGYHLGSYAPPCASP------PKDDFS--- 105
            |:|.|..|.       |:|.:|.|.|||....:..:.|..|. |.|.|||      |..|||
Human    46 SSYSHVEPA-------PAPPTAWGAPFPAPKDDWAAAYGPGP-AAPAASPASLAFGPPPDFSPVP 102

  Fly   106 ---------------------------------ISDKCEDSGLRVNGKGKKMRKPRTIYSSLQLQ 137
                                             :.......|...:||.:...|.|.:|:..|..
Human   103 APPGPGPGLLAQPLGGPGTPSSPGAQRPTPYEWMRRSVAAGGGGGSGKTRTKDKYRVVYTDHQRL 167

  Fly   138 QLNRRFQRTQYLALPERAELAASLGLTQTQVKIWFQNRRSKYKKMMKAAQG-------------P 189
            :|.:.|..::|:.:..::||||:||||:.||||||||||:|.:|:.|..|.             .
Human   168 ELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQPPQPPMAHDIT 232

  Fly   190 GTNSGMPLGGGGPN 203
            .|.:|..|||..|:
Human   233 ATPAGPSLGGLCPS 246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dll	NP_001137759.1	Homeodomain	125..181	CDD:459649	26/55 (47%)
CDX1	NP_001795.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	9..153		25/114 (22%)
		Caudal_act	13..142	CDD:461413	22/103 (21%)
		Homeodomain	156..211	CDD:459649	26/54 (48%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536	157..178		5/20 (25%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	196..207		9/10 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..265		10/40 (25%)