DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc4 and orc4

DIOPT Version :9

Sequence 1:	NP_477320.1	Gene:	Orc4 / 37970	FlyBaseID:	FBgn0023181	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_998348.1	Gene:	orc4 / 406462	ZFINID:	ZDB-GENE-040426-2224	Length:	432	Species:	Danio rerio

Alignment Length:	462	Identity:	202/462 - (43%)
Similarity:	277/462 - (59%)	Gaps:	49/462 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ADRELVS-IRRFLKERL--QRDYTTLRGYAKERSNVRLLLQRTAEMGESNSLLLLGPRGSGKTTL 65
            :|.:.|| ::..|:|||  |:......|...:..::..||:|||..|||||:|::||||||||.|
Zfish    10 SDVQCVSLVQELLRERLCHQKLPDQPIGLDSQYKHLLELLRRTAVHGESNSVLIVGPRGSGKTML 74

  Fly    66 INSVLADLLPNKSFGENTLIVHLDGNLHTDDRVALKSITVQMQLENAADGKVFGSFAENLAFLLQ 130
            :..||.:|:..|...:|.|:|.|:|.|.|||::|||.||.|:.|||....||||||||||||||:
Zfish    75 LGCVLRELMSLKEVQKNVLLVELNGLLQTDDKIALKEITRQLHLENVVGDKVFGSFAENLAFLLE 139

  Fly   131 CLKAGGK-HSKSVIFILEEFDLFCAHHNQTLLYNLFDVSQSAQAPICVLGVTCRLDVIELLEKRV 194
            .||.|.| .|:.|:|:|:|||||..|.||||||||.|||||||.|:.|:|.||||||:|||||||
Zfish   140 ALKKGDKSSSRPVLFLLDEFDLFAHHKNQTLLYNLLDVSQSAQTPVAVVGFTCRLDVLELLEKRV 204

  Fly   195 KSRFSHRQVFLFPSLRRFEDYVDLCRDLLSLPTGNSLLLAAEKIYNLQNIQSGALYFSRNHFDPG 259
            ||||||||:.||.|| .|..|||:.|..||||.                             |..
Zfish   205 KSRFSHRQIHLFSSL-SFSQYVDVVRLQLSLPQ-----------------------------DFP 239

  Fly   260 EYGFSPRLRDAWNKQICKVLATQQARSTLQAL-HDFDISEAY--LKNFLFRLVAHLRPQSPHITA 321
            ::.||.:    ||:.:.|:.   :.:|.|:.| ..|:.|:.:  |.:.||..|:.:......:..
Zfish   240 DHRFSSQ----WNQSVTKLC---EDKSVLEVLKRSFNSSKDFRSLFSLLFMAVSRVSVSHSTLCE 297

  Fly   322 EKMAAVGSQFEGDDKIELLCGLSVLELCLIIAIKHHSQIYDRDSFNFEIIYARFSKF-AKVSTTM 385
            ......|.....|.|..:|.|||:||||||||:||.:..||.:.|||::::..|.|| .:.|.::
Zfish   298 ADFLESGRLISADSKANVLHGLSILELCLIIAMKHLNDTYDGEPFNFQMVHNEFKKFIQRKSHSI 362

  Fly   386 QAVERSIVLKAFEHLRIAELIMPLTGGAGGGVGKVQKEFEMHKLALTYSQIHHCMQRYQALPTEV 450
            ...|:.:|:||||||...||:.|:    ..||.|||:|:::.:|.|.:.|:...:|||...||:|
Zfish   363 HKFEKPVVMKAFEHLLQLELVRPV----DSGVCKVQREYQLMRLMLEHGQVMEALQRYPQCPTDV 423

  Fly   451 AQWAQSS 457
            .|||.|:
Zfish   424 KQWALSA 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc4	NP_477320.1	AAA_16	39..178	CDD:289934	86/139 (62%)
		AAA	50..205	CDD:214640	101/155 (65%)
		ORC4_C	257..430	CDD:291303	58/176 (33%)
orc4	NP_998348.1	AAA_16	34..188	CDD:289934	87/153 (57%)
		AAA	59..215	CDD:214640	101/155 (65%)
		ORC4_C	226..403	CDD:291303	64/216 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578991
Domainoid	1	1.000	167	1.000	Domainoid score	I3823
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8059
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2461
OMA	1	1.010	-	-		QHG55839
OrthoDB	1	1.010	-	-		D1543398at2759
OrthoFinder	1	1.000	-	-		FOG0005811
OrthoInspector	1	1.000	-	-		oto41387
orthoMCL	1	0.900	-	-		OOG6_103029
Panther	1	1.100	-	-	LDO	PTHR12087
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R873
SonicParanoid	1	1.000	-	-		X4202
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940