DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc4 and Orc4

DIOPT Version :9

Sequence 1:	NP_477320.1	Gene:	Orc4 / 37970	FlyBaseID:	FBgn0023181	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	XP_038960388.1	Gene:	Orc4 / 295596	RGDID:	735212	Length:	461	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	198/475 - (41%)
Similarity:	271/475 - (57%)	Gaps:	68/475 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVSIRRFLKERL--QRDYTTLRGYAKERSNVRLLLQRTAEMGESNSLLLLGPRGSGKTTLINSVL 70
            |..::|.|:||.  ...::.|.|...:..::..||:|||..|||||||::||||||||||:|..|
  Rat    28 LSQVQRILRERFCHHTPHSNLFGVQVQYKHLIELLKRTAIYGESNSLLIVGPRGSGKTTLLNHAL 92

  Fly    71 ADLLPNKSFGENTLIVHLDGNLHTDDRVALKSITVQMQLENAADGKVFGSFAENLAFLLQCLKAG 135
            .:|:......||.|.|||:|.|.|:|::|||.||.|:.|||....||||||||||:|||:.|:.|
  Rat    93 KELMQIGDMSENVLQVHLNGLLQTNDKIALKEITRQLNLENVVGDKVFGSFAENLSFLLEALQKG 157

  Fly   136 GKHSK-SVIFILEEFDLFCAHHNQTLLYNLFDVSQSAQAPICVLGVTCRL--------------D 185
            .:.|. .|||||:|||||....||||||||||:|||||.||.|:|:||||              |
  Rat   158 NRTSSCPVIFILDEFDLFAHQKNQTLLYNLFDISQSAQTPIAVIGLTCRLLILRRSELLKVYFHD 222

  Fly   186 VIELLEKRVKSRFSHRQVFLFPSLRRFEDYVDLCRDLLSLPTGNSLLLAAEKIYNLQNI-----Q 245
            ::|||||||||||||||:.|..|. .|..|:.:.::.||||......:.||| :| :|.     .
  Rat   223 ILELLEKRVKSRFSHRQIHLMNSF-DFPQYLKIFKEQLSLPAEFPDKIFAEK-WN-ENAHCLSED 284

  Fly   246 SGALYFSRNHFDPGEYGFSPRLRDAWNKQICKVLATQQARSTLQALHDFDISEAYLKNFLFRL-V 309
            |..|...:.||:                          ....||:||      ..|...|.|: |
  Rat   285 STVLEVLQKHFN--------------------------VNKNLQSLH------MLLMLALNRVTV 317

  Fly   310 AHLRPQSPHITAEKMAAVGSQFEGDDKIELLCGLSVLELCLIIAIKHHSQIYDRDSFNFEIIYAR 374
            .|     |.:|:..:.........|.|..::.||||||:|||||:||.:.||:.:.|||:::|..
  Rat   318 TH-----PFMTSADLMEAQHLCSLDAKASIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNE 377

  Fly   375 FSKF-AKVSTTMQAVERSIVLKAFEHLRIAELIMPLTGGAGGGVGKVQKEFEMHKLALTYSQIHH 438
            |.|| .:.:.::...|:.:|:||||||:..|||.|:...:...    |:|:::.||.|..:||.:
  Rat   378 FQKFIQRKAHSVYNFEKPVVMKAFEHLQQLELIKPMERTSVNS----QREYQLVKLLLDNTQIMN 438

  Fly   439 CMQRYQALPTEVAQWAQSSL 458
            .:|:|...||:|.|||.|||
  Rat   439 ALQKYSNCPTDVRQWATSSL 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc4	NP_477320.1	AAA_16	39..178	CDD:289934	87/139 (63%)
		AAA	50..205	CDD:214640	101/169 (60%)
		ORC4_C	257..430	CDD:291303	50/174 (29%)
Orc4	XP_038960388.1	CDC6	54..>251	CDD:224391	117/211 (55%)
Orc4	XP_038960388.1	ORC4_C	253..440	CDD:405334	56/193 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339295
Domainoid	1	1.000	167	1.000	Domainoid score	I3764
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8059
Inparanoid	1	1.050	310	1.000	Inparanoid score	I2524
OMA	1	1.010	-	-		QHG55839
OrthoDB	1	1.010	-	-		D1543398at2759
OrthoFinder	1	1.000	-	-		FOG0005811
OrthoInspector	1	1.000	-	-		oto95934
orthoMCL	1	0.900	-	-		OOG6_103029
Panther	1	1.100	-	-	LDO	PTHR12087
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4202
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910