DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orc4 and Orc4

DIOPT Version :9

Sequence 1:	NP_477320.1	Gene:	Orc4 / 37970	FlyBaseID:	FBgn0023181	Length:	459	Species:	Drosophila melanogaster
Sequence 2:	NP_001342225.1	Gene:	Orc4 / 26428	MGIID:	1347043	Length:	433	Species:	Mus musculus

Alignment Length:	466	Identity:	191/466 - (40%)
Similarity:	272/466 - (58%)	Gaps:	65/466 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVSIRRFLKERL--QRDYTTLRGYAKERSNVRLLLQRTAEMGESNSLLLLGPRGSGKTTLINSVL 70
            |..::|.|:||.  ...::.|.|...:..::..||:|||..|||||:|::||||||||||:|..|
Mouse    15 LSQVQRILRERFCHHSPHSNLFGVQVQYKHLIELLKRTAIYGESNSVLIVGPRGSGKTTLLNHAL 79

  Fly    71 ADLLPNKSFGENTLIVHLDGNLHTDDRVALKSITVQMQLENAADGKVFGSFAENLAFLLQCLKAG 135
            .:|: .....||.:.|||:|.|.|::::|||.||.|:.|:|..:.||||||||||:|||:.|:.|
Mouse    80 KELM-EIEVSENVIQVHLNGLLQTNEKIALKEITRQLNLDNVVEDKVFGSFAENLSFLLEALQKG 143

  Fly   136 GKHSK-SVIFILEEFDLFCAHHNQTLLYNLFDVSQSAQAPICVLGVTCRLDVIELLEKRVKSRFS 199
            .:.|. .|||||:|||:|....||||||||||:|||||.|:.|:|:|||||::||||||||||||
Mouse   144 DRTSSCPVIFILDEFDIFAHQKNQTLLYNLFDISQSAQTPVAVIGLTCRLDILELLEKRVKSRFS 208

  Fly   200 HRQVFLFPSLRRFEDYVDLCRDLLSLPTGNSLLLAAEKIYNLQNIQSGALYFSRNHFDPGEYGFS 264
            |||:.|..|. .|..|:.:.::.||||.                             :..:..|:
Mouse   209 HRQIHLMNSF-DFPQYLKIFKEQLSLPA-----------------------------EFPDKAFA 243

  Fly   265 PRLRDAWNKQI-C-----KVLATQQ----ARSTLQALHDFDISEAYLKNFLFRL-VAHLRPQSPH 318
            .|    ||:.: |     .||...|    ....||:||      ..|...|.|: |:|     |.
Mouse   244 ER----WNENVHCLSEDSTVLEVLQKHFSVNKNLQSLH------MLLMLALNRVTVSH-----PF 293

  Fly   319 ITAEKMAAVGSQFEGDDKIELLCGLSVLELCLIIAIKHHSQIYDRDSFNFEIIYARFSKF-AKVS 382
            :|:..:.........|.|..::.||||||:|||||:||.:.||:.:.|||:::|..|.|| .:.:
Mouse   294 MTSADLMEAQHMCSLDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQKFIQRKA 358

  Fly   383 TTMQAVERSIVLKAFEHLRIAELIMPLTGGAGGGVGKVQKEFEMHKLALTYSQIHHCMQRYQALP 447
            .::...|:.:|:||||||:..|||.|:...:...    |:|:::.||.|..:||.:.:|:|...|
Mouse   359 HSVYNFEKPVVMKAFEHLQQLELIKPVERTSVNS----QREYQLVKLLLDNTQIMNALQKYSNCP 419

  Fly   448 TEVAQWAQSSL 458
            |:|.|||.|||
Mouse   420 TDVRQWATSSL 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orc4	NP_477320.1	AAA_16	39..178	CDD:289934	81/139 (58%)
		AAA	50..205	CDD:214640	95/155 (61%)
		ORC4_C	257..430	CDD:291303	58/184 (32%)
Orc4	NP_001342225.1	CDC6	41..>223	CDD:224391	106/182 (58%)
Orc4	NP_001342225.1	ORC4_C	225..412	CDD:373172	55/198 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835670
Domainoid	1	1.000	158	1.000	Domainoid score	I4132
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8059
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2666
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55839
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005811
OrthoInspector	1	1.000	-	-		oto92365
orthoMCL	1	0.900	-	-		OOG6_103029
Panther	1	1.100	-	-	LDO	PTHR12087
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R873
SonicParanoid	1	1.000	-	-		X4202
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.930