DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF3C and Kif3c

DIOPT Version :9

Sequence 1:	NP_002245.4	Gene:	KIF3C / 3797	HGNCID:	6321	Length:	793	Species:	Homo sapiens
Sequence 2:	NP_445938.1	Gene:	Kif3c / 85248	RGDID:	621538	Length:	796	Species:	Rattus norvegicus

Alignment Length:	796	Identity:	764/796 - (95%)
Similarity:	778/796 - (97%)	Gaps:	3/796 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYD 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYD 65

Human    66 ASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTH 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 ASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTH 130

Human   131 ISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVM 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 ISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVM 195

Human   196 NLGNQTRAVGSTHMNEVSSRSHAIFIITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNT 260
            |||||.|||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||
  Rat   196 NLGNQARAVGSTHMNEVSSRSHAIFVITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNT 260

Human   261 AGGAATPSSGGGGGGGG--SGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLT 323
            .||.||.|:.|||||||  ||.|:.||||||||||||||||||||||||||||||||||||||||
  Rat   261 PGGPATQSTAGGGGGGGGTSGSGSSGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLT 325

Human   324 RLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIA 388
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 RLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIA 390

Human   389 RLKAQLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPILESAL 453
            ||||||||:|||||||||||||||||||||.|||||.||||||||||||||||||||||.||:||
  Rat   391 RLKAQLEKKGMLGKRPRRKSSRRKKAVSAPAGYPEGAVIEAWVAEEEDDNNNNHRPPQPTLEAAL 455

Human   454 EKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKAME 518
            |||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
  Rat   456 EKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLKREQQATELLAAKYKAME 520

Human   519 SKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMMLRDEETMELRGTYTSLQQEVEV 583
            ||||||||||||||||||||||||||||||||||||||||||:|||||||||||||:||||||||
  Rat   521 SKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMLLRDEETMELRGTYSSLQQEVEV 585

Human   584 KTKKLKKLYAKLQAVKAEIQDQHDEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMN 648
            |||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||
  Rat   586 KTKKLKKLYAKLQAVKAEIQDQHEEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMN 650

Human   649 RLFLDCEEEQWKFQPLVPAGVSSSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENIMFLE 713
            |||||||||||||||||||||::||||||||||||||||||||||||||||||||||||||||||
  Rat   651 RLFLDCEEEQWKFQPLVPAGVNNSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENIMFLE 715

Human   714 LDVSPPAVFEMEFSHDQEQDPRALHMERLMRLDSFLERPSTSKVRKSRSWCQSPQR-PPPSTTHA 777
            |||||||:||||||||||||||.||||||||||||||||||||||||||||||||| |||||.||
  Rat   716 LDVSPPAIFEMEFSHDQEQDPRVLHMERLMRLDSFLERPSTSKVRKSRSWCQSPQRPPPPSTVHA 780

Human   778 SLASASLRPATVADHE 793
            |:|||.|.||||.||:
  Rat   781 SMASAPLHPATVVDHD 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF3C	NP_002245.4	KISc_KIF3	9..365	CDD:276822	345/357 (97%)
		Kinesin	16..365	CDD:278646	338/350 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..288		28/38 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..424		26/28 (93%)
		GBP_C	<461..569	CDD:303769	105/107 (98%)
		coiled coil	538..549	CDD:293879	10/10 (100%)
		coiled coil	558..569	CDD:293879	9/10 (90%)
		Globular. /evidence=ECO:0000255	630..793		153/163 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	750..793		37/43 (86%)
Kif3c	NP_445938.1	KISc_KIF3	9..367	CDD:276822	345/357 (97%)
		Kinesin	16..367	CDD:278646	338/350 (97%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..292		30/40 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..421		22/23 (96%)
		GBP_C	<463..571	CDD:303769	105/107 (98%)
		coiled coil	540..551	CDD:293879	10/10 (100%)
		coiled coil	560..571	CDD:293879	9/10 (90%)
		Globular. /evidence=ECO:0000255	633..793		150/159 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..796		35/41 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83681787
Domainoid	1	1.000	810	1.000	Domainoid score	I2584
eggNOG	1	0.900	-	-		E2759_KOG4280
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55640
Inparanoid	1	1.050	1501	1.000	Inparanoid score	I2734
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D108497at7742
OrthoFinder	1	1.000	-	-		FOG0002745
OrthoInspector	1	1.000	-	-		oto131320
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1829
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	17.260