DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF3C and Kif3C

DIOPT Version :9

Sequence 1:	NP_002245.4	Gene:	KIF3C / 3797	HGNCID:	6321	Length:	793	Species:	Homo sapiens
Sequence 2:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	730	Identity:	253/730 - (34%)
Similarity:	375/730 - (51%)	Gaps:	133/730 - (18%)

- Green bases have known domain annotations that are detailed below.

Human     8 SEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQAD 72
            ||.:|||.||||:::.|:....:.|  :::....|::.||.|...: .|.|.||:||:..:....
  Fly     2 SENIKVVVRCRPMNQTEKERNCQNI--VEINEFAVSVTNPSARISQ-QKKFIFDSVYNMKTDTEV 63

Human    73 LYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQ 137
            :|||....|::|.::|:|||:|||||||.|||:||||........|:||..|:|||..||.:.|.
  Fly    64 IYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTTNV 128

Human   138 QYLVRASYLEIYQEEIRDLLSKEPGKRL---ELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGN 199
            :||...:|||||.|.|||||:|.....:   .|||.|..||.:..|::....|..:....::.||
  Fly   129 RYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGN 193

Human   200 QTRAVGSTHMNEVSSRSHAIFIITVECS----ERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNT 260
            :.|...:|.||:.|||||.||.||:|.|    ..|||....|..|||:||||||||||.|.
  Fly   194 KNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKT---- 254

Human   261 AGGAATPSSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRL 325
                                ||.|:|.||||:||||||||||||::|...::.|:|:||||||||
  Fly   255 --------------------GAQGDRLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRL 299

Human   326 LQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARL 390
            ||||||||.||:|::.:.|....|||::||||:|:|||||.|||::||||||..||::|.||..|
  Fly   300 LQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYL 364

Human   391 KAQLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPILESALE- 454
            |..|::                                    .::..|.||  .|..|::|.|:
  Fly   365 KRMLQE------------------------------------SQQIINKNN--DPNKIIKSPLKI 391

Human   455 ---KNMENYLQEQKERLEEE-KAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYK 515
               .||.:....|...|... ||:.:.:.|::::....|::.||::           :|.|....
  Fly   392 IQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNFPLIQSKEEV-----------QLQARSRI 445

Human   516 AMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMM----LRDEETMELRGTYTS 576
            .:..:.||||..|.|        .|||.:.:|.:...:|.:....:    ::.|:...|:|.|.:
  Fly   446 DLIKRSLIGGERIHD--------FELKEKHMARKYAAQRHLSAIAIALSRVKCEDRDLLQGHYAT 502

Human   577 LQQEVEVKTKKLKKLYAKLQAVKAEIQDQHDEYIRVRQD-LEEAQN--EQTR---ELKLKY---- 631
            :.||:::|...::|...|::.::.|:.|.:.|:...|:| |:|.:|  .|.:   :|.||:
  Fly   503 ITQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDREDYLDEIRNLGRQVKFHQQLFLKFSSNP 567

Human   632 -LIIENFIPPEEKNKIMNRLFLDCEEEQWKFQ-----PLVPA----GV---------SSSQMKKR 677
             ....|:.|   ...:.|.|:.| :.:.|:..     .|.||    |:         |.:|...:
  Fly   568 GKFDRNWTP---DTILQNSLWND-DLKMWRIPESDLIKLPPATQKSGLHCIHPLVIHSENQHNNQ 628

Human   678 PTSAVGYKRPISQYA 692
            ....||.|..||..|
  Fly   629 NEIVVGEKVSISNIA 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF3C	NP_002245.4	KISc_KIF3	9..365	CDD:276822	164/362 (45%)
		Kinesin	16..365	CDD:278646	160/355 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..288		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..424		0/28 (0%)
		GBP_C	<461..569	CDD:303769	22/112 (20%)
		coiled coil	538..549	CDD:293879	4/10 (40%)
		coiled coil	558..569	CDD:293879	1/14 (7%)
		Globular. /evidence=ECO:0000255	630..793		19/86 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	750..793
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	164/362 (45%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	160/355 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820