DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF3C and kif3c

DIOPT Version :9

Sequence 1:	NP_002245.4	Gene:	KIF3C / 3797	HGNCID:	6321	Length:	793	Species:	Homo sapiens
Sequence 2:	XP_002661420.3	Gene:	kif3c / 100333558	-ID:	-	Length:	754	Species:	Danio rerio

Alignment Length:	783	Identity:	541/783 - (69%)
Similarity:	637/783 - (81%)	Gaps:	48/783 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASKTKASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYD 65
            |:.|:|..|::|||.|||||:||||::|:|.|:.||||||||.|||.:|.||:|.||||||||||
Zfish     1 MSMKSKTGESVKVVVRCRPLNRKEESSGYENIVQMDVKLGQVALRNAKAGPGDLLKTFTFDAVYD 65

Human    66 ASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTH 130
            ..|||.|||||||||||||||:|||||:||||||||||||||||.|::.|.||:|||:|||||||
Zfish    66 ECSKQGDLYDETVRPLIDSVLRGFNGTIFAYGQTGTGKTYTMQGQWLDAERRGIIPNSFEHIFTH 130

Human   131 ISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKENPETGVYIKDLSSFVTKNVKEIEHVM 195
            |||||||||||||||||||||||||||:|:..|:|||||:.::||||||||||||||||||||||
Zfish   131 ISRSQNQQYLVRASYLEIYQEEIRDLLTKDHSKKLELKESADSGVYIKDLSSFVTKNVKEIEHVM 195

Human   196 NLGNQTRAVGSTHMNEVSSRSHAIFIITVECSERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNT 260
            |:|||||:||.|:|||.|||||||||||||||:.|.|||:||||||||||||||||||.|.
Zfish   196 NVGNQTRSVGFTNMNEHSSRSHAIFIITVECSQLGPDGQNHIRVGKLNLVDLAGSERQTKT---- 256

Human   261 AGGAATPSSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLTRL 325
                                |..|||.|||:|||||||||||||:||...||:|:||||||||||
Zfish   257 --------------------GVQGERLKEATKINLSLSALGNVISALVDGRSSHVPYRDSKLTRL 301

Human   326 LQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIARL 390
            |||||||||||||||||||||::|:|:|:|||:|||||||||||||||||||.||||||||||||
Zfish   302 LQDSLGGNAKTIMVATLGPASYNYEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQEEIARL 366

Human   391 KAQLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEEEDDNNNNHRPPQPILESALEK 455
            ||||:|||||.||.||  |||.:.:    |..|        .|||||..:...      |..:||
Zfish   367 KAQLDKRGMLTKRKRR--SRRLRKI----GEEE--------VEEEDDLEDYDD------EEIVEK 411

Human   456 NMENYLQEQKERLEEEKAAIQDDRSLVSEEKQKLLEEKEKMLEDLRREQQATELLAAKYKAMESK 520
            ..:.|::||:|.||.||.||:||.|||:||||:||||||:|:..|::||:|||:|.||:||||||
Zfish   412 EAQEYMKEQQEELEREKEAIRDDHSLVAEEKQRLLEEKERMMRHLKKEQEATEMLTAKFKAMESK 476

Human   521 LLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEMMLRDEETMELRGTYTSLQQEVEVKT 585
            ||:||:||:|||||||||||.||.|||||.|||||:||:::.:||||:|||.|::|||||||.||
Zfish   477 LLVGGKNIIDHTNEQQKMLEQKRHEIAEQTRREREIQQQLLDQDEETLELRETFSSLQQEVEAKT 541

Human   586 KKLKKLYAKLQAVKAEIQDQHDEYIRVRQDLEEAQNEQTRELKLKYLIIENFIPPEEKNKIMNRL 650
            |||||||||||::||:|||.:||::|.|||||:.|||.|||||.|||||||||||||||||||||
Zfish   542 KKLKKLYAKLQSLKADIQDVNDEHVRSRQDLEQTQNELTRELKFKYLIIENFIPPEEKNKIMNRL 606

Human   651 FLDCEEEQWKFQPLVPAGVSSSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRYRAENIMFLELD 715
            ..|.||:||||||||||....:|||:||.||||||||||||||||||||:|.||||||||.||||
Zfish   607 EFDAEEDQWKFQPLVPAENKFTQMKRRPASAVGYKRPISQYARVAMAMGAHSRYRAENIMLLELD 671

Human   716 VSPPAVFEMEFSHD-QEQDPRALHMERLMRLDSFLERPSTSKVRKSRSWCQSPQRPPPSTTHASL 779
            ::||.||::|.... .|::|   ..:.|:..:|:.|:.:..:||||:|||||.|..|.|::..||
Zfish   672 MTPPVVFQLELQKSGSEEEP---SRDVLLDNNSYREKSAAGRVRKSQSWCQSQQVMPTSSSALSL 733

Human   780 ASA 782
            ||:
Zfish   734 ASS 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF3C	NP_002245.4	KISc_KIF3	9..365	CDD:276822	267/355 (75%)
		Kinesin	16..365	CDD:278646	263/348 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..288		8/36 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..424		13/28 (46%)
		GBP_C	<461..569	CDD:303769	75/107 (70%)
		coiled coil	538..549	CDD:293879	8/10 (80%)
		coiled coil	558..569	CDD:293879	5/10 (50%)
		Globular. /evidence=ECO:0000255	630..793		98/154 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	750..793		17/33 (52%)
kif3c	XP_002661420.3	KISc_KIF3	9..341	CDD:276822	267/355 (75%)
kif3c	XP_002661420.3	SMC_N	<411..>584	CDD:330553	120/172 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194329376
Domainoid	1	1.000	503	1.000	Domainoid score	I2722
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1034	1.000	Inparanoid score	I2167
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D108497at7742
OrthoFinder	1	1.000	-	-		FOG0002745
OrthoInspector	1	1.000	-	-		oto48665
orthoMCL	1	0.900	-	-		OOG6_101005
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2170
SonicParanoid	1	1.000	-	-		X1829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790