DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment key and Optn

DIOPT Version :9

Sequence 1:NP_001246503.1 Gene:key / 37967 FlyBaseID:FBgn0041205 Length:389 Species:Drosophila melanogaster
Sequence 2:NP_001343416.1 Gene:Optn / 71648 MGIID:1918898 Length:584 Species:Mus musculus


Alignment Length:456 Identity:98/456 - (21%)
Similarity:173/456 - (37%) Gaps:126/456 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SDEESFVILGSSPCSSLMPDSSLRSDVCGNAQEAKETVASTSTQPPTVNCIPVSITASQQQHKSL 66
            |.|:|||.:..:           ..:..|..:|.|.....|.|.       |:|::...:..:| 
Mouse   183 SSEDSFVEIRMT-----------EGETEGAMKEMKNCPTPTRTD-------PISLSNCTEDARS- 228

  Fly    67 DSGSSQQQSLATSFIMGEIQSDVLKNSVYSQFPSLCSLQGSAEEVVKLQNMMTEYLALKSTLDKV 131
               .::.:.|..|.::                  ||..:|: ::|.:|:      :||:...:::
Mouse   229 ---CAEFEELTVSQLL------------------LCLREGN-QKVERLE------VALREAKERI 265

  Fly   132 N--QTMLNYHNLTQQWRQEAADREHQYK------EHVKECQAQIAILRVENQE----------LK 178
            :  :...|.|:.|::.....||||.:.|      ..|:....|:..|..|.||          :|
Mouse   266 SDFEKKANGHSSTEKQTARRADREKEDKGQESVGSEVETLSIQVTSLFKELQEAHTKLSEAELMK 330

  Fly   179 RDLETKIEQIEGVHTI---RLKEQDELRKSVSEKQSLIDNMRVEIDK------------------ 222
            :.|:.|.:.:|..::.   .|.|:.||..|..:.:..:::||.||..                  
Mouse   331 KRLQEKCQALERKNSATPSELNEKQELVYSNKKLELQVESMRSEIKMEQAKTEEEKSRLATLQAT 395

  Fly   223 ----LKQLNHSFEFVPEYATESKS-------QELIKKM----------QLDINELK---ARDIQK 263
                |::.|.:.:.:.|...:...       |||.:|:          ||.::|:|   |:..:.
Mouse   396 HNKLLQEHNKALKTIEELTKQQAEKVDKMLLQELSEKLELAEQALASKQLQMDEMKQTLAKQEED 460

  Fly   264 QEVIKGLQIQNDIYRRDFEMERADREKNAGEKDQYLMDLRSLQRRNQELIEALAESHKASKACST 328
            .|.:..|:.|.::|..||..|||.|||...||:|..:.|..|.:.|.::.|..:........|..
Mouse   461 LETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENNDIEEGGSRQSLMEMQCRH 525

  Fly   329 ASPLSSSRSNLREEQRPVRILDPTGASSRT--------SDTTLRCPICSKSFNALSVLQSHVNDC 385
            .:..|.|.......||        ||..|:        |.....||.|.:....:..||.||.||
Mouse   526 GARTSDSDQQTYLFQR--------GAEDRSWQHGQQPRSIPIHSCPKCGEVLPDIDTLQIHVMDC 582

  Fly   386 L 386
            :
Mouse   583 I 583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
keyNP_001246503.1 DUF499 <168..>351 CDD:303008 53/237 (22%)
UBAN 230..313 CDD:197361 28/102 (27%)
OptnNP_001343416.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32
NEMO 37..103 CDD:371612
Interaction with Rab8. /evidence=ECO:0000250 58..219 11/53 (21%)
Smc <77..424 CDD:224117 52/287 (18%)
LIR 186..191 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 267..302 8/34 (24%)
CC2-LZ 411..507 CDD:406823 27/95 (28%)
Interaction with HD. /evidence=ECO:0000250 414..584 46/178 (26%)
Interaction with MYO6. /evidence=ECO:0000250 415..524 28/108 (26%)
UBAN 477..482 2/4 (50%)
zf_C2H2_10 558..583 CDD:375840 8/24 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 68 1.000 Inparanoid score I5326
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007215
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.920

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