DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment key and ikbkg

DIOPT Version :9

Sequence 1:	NP_001246503.1	Gene:	key / 37967	FlyBaseID:	FBgn0041205	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	XP_005162127.1	Gene:	ikbkg / 541530	ZFINID:	ZDB-GENE-050327-68	Length:	602	Species:	Danio rerio

Alignment Length:	426	Identity:	101/426 - (23%)
Similarity:	166/426 - (38%)	Gaps:	120/426 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LRSDVCGNAQEAKETVASTSTQPPTVNC-------------IPVSITASQQQHKSL--------- 66
            |||.:..|....:|:|      |||  |             |...:.|:|.:::.|
Zfish   233 LRSKLSQNVGVTEESV------PPT--CAVTVPAESSHLANITEQLQATQGRYRELQEKLDCLQK 289

  Fly    67 -----DSGSSQQQSLATSFIMGEIQSDVLKNSVYSQFPSLCSLQGSAEEVVKLQNMMTEYLALKS 126
                 |...:..:.....|:..:..|:.|::.|       .||.|   |:.:.||.:.:..|.|.
Zfish   290 NSFQRDRTEALLKQKEKEFVQVQKDSEALRSQV-------TSLLG---ELNERQNWLEKSEAEKR 344

  Fly   127 TL-DKVNQTMLNYHNLTQQWRQEAADREHQYKEHVKECQAQIAILRVENQE--LKRDL------E 182
            || ||:         :|:..|.:..:||.:.::..........:|:.:|.|  ||.:.      .
Zfish   345 TLEDKL---------VTKSERLQTVEREMEQQKKQHSVTVDNLLLKTQNLEAALKNERLVIVEER 400

  Fly   183 TKIEQIEGVHTIRLKEQDELRKSVSEKQSLIDNMRVEIDKL-KQLNHSFEFVPEYATESKSQELI 246
            .|:.|::..:|...::.|  .|..||||:  ::...|.|.| .:|..:     |.|...| ||.|
Zfish   401 RKLAQLQHAYTCLFQDYD--NKLKSEKQA--NHRGGETDTLANRLGEA-----EKALALK-QEHI 455

  Fly   247 KKMQLDINELKARDIQKQEVIKGLQIQNDIYRRDFEMERADREKNAGEKDQYLMDLR----SLQR 307
            .|::.::.:|:|    |.|.|..|..|.:||:.||..||..|||...:|::...||.    .::|
Zfish   456 DKLKEEMEQLRA----KLETIPVLNHQAEIYKMDFLAEREAREKLNQKKEELQEDLNKALVEIER 516

  Fly   308 RNQE-----LIEALAESH-----------------KASKACSTASPLSSSRSNLREEQRPVRILD 350
            ..||     .||.:.:.|                 ......::|.|.|:.|.:..:|:.|
Zfish   517 FKQERTSRARIEEMQQRHLEDYRPRPHPPPPAAPFPGPAMFNSAQPPSARRRDEDQEELP----- 576

  Fly   351 PTGASSRTSDTTLRCPICSKSFNALSVLQSHVNDCL 386
                       ..|||.|......:..||.||.||:
Zfish   577 -----------DYRCPKCMYKAPDMDTLQIHVMDCI 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
key	NP_001246503.1	DUF499	<168..>351	CDD:303008	56/217 (26%)
key	NP_001246503.1	UBAN	230..313	CDD:197361	29/91 (32%)
ikbkg	XP_005162127.1	NEMO	43..110	CDD:288434
ikbkg	XP_005162127.1	UBAN	432..518	CDD:197361	31/95 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	59	1.000	Inparanoid score	I5407
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D326045at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.930