DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment key and Optn

DIOPT Version :9

Sequence 1:	NP_001246503.1	Gene:	key / 37967	FlyBaseID:	FBgn0041205	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	XP_017455943.1	Gene:	Optn / 246294	RGDID:	628886	Length:	660	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	101/506 - (19%)
Similarity:	185/506 - (36%)	Gaps:	155/506 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RSDVCGNAQEAKETVASTSTQPPTVNCIPVSITASQQQHKSLDSGSSQQQSLATSFIMGEIQSDV 89
            ::|:.|...|.:..:.|:.:...:.  :.:.:|..:.:....:..:|...:...|..||:...|.
  Rat   165 KADLLGIVSELQLKLNSSGSSEDSF--VEIRMTEGEAEGAMKEMRNSAGPTRTDSISMGKCTEDA 227

  Fly    90 -----LKNSVYSQFPSLCSLQGSAEEVVKLQNMMTEYLALKSTLDKVN--QTMLNYHNLTQQWRQ 147
                 .:....||. .||..:|: ::|.:|:      :||:...::::  :...|.|:..:...:
  Rat   228 RTCVEFEELTVSQL-LLCLREGN-QKVERLE------IALREAKERISDFEKKANGHSAIETQTE 284

  Fly   148 EAADREHQYKE------HVKECQAQIAILRVENQE----------LKRDLETKIEQIEGVHTI-- 194
            .:..:|.:.|:      .|:....|:|.|..|.||          :|:.|:.|.:.:|..::.
  Rat   285 GSTQKEEEDKDPESVGIEVETLNVQVASLFKELQEAHTKLSEAELMKKRLQEKCQALERKNSATP 349

  Fly   195 -RLKEQDELRKSVSEKQSLIDNMRVEI---------------------DKLKQLNHSFEFVPEYA 237
             .|.|:.||..|..:.:..:::||.||                     |||.|.::......|..
  Rat   350 SELNEKQELVYSNRKLELQVESMRSEIKMEQAKTEEEKSRLATLQATHDKLLQEHNKALRTIEEL 414

  Fly   238 TESKS--------QELIKKM----------QLDINELKARDIQKQ----EVIKGLQIQNDIYRRD 280
            |:.::        |||.:|:          ||.::|:| :.|.||    |.:..|:.|.::|..|
  Rat   415 TKQQAEKVDKVQLQELSEKLELAEQALASKQLQMDEMK-QTIAKQEEDLETMAVLRAQMEVYCSD 478

  Fly   281 FEMERADREKNAGEKDQYLMDLRSLQRRNQEL--------------------IEALAES----HK 321
            |..|||.|||...||:|..:.|..|.:.|.:.                    :.:|.:|    |:
  Rat   479 FHAERAAREKIHEEKEQLALQLAILLKENNDFEDGGRCGRLPQSVYGDHRTGVSSLPQSVYGDHR 543

  Fly   322 ASKACSTASPLSSSRSNLREEQRPVRILDPTGASS-------------------------RTSDT 361
            ...:....|.....|:.:......|.....||.||                         ||||:
  Rat   544 TGVSSLPQSVYGDHRTGVSSLPHSVYGDHRTGVSSLPHSVYGDHRTGRQSLMEMQCRHGARTSDS 608

  Fly   362 TLR--------------------------CPICSKSFNALSVLQSHVNDCL 386
            ..:                          ||.|.:....:..||.||.||:
  Rat   609 DQQAYLFQRGAEDMSWQHGQQPRSIPIHSCPKCGEVLPDIDTLQIHVMDCI 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
key	NP_001246503.1	DUF499	<168..>351	CDD:303008	59/262 (23%)
key	NP_001246503.1	UBAN	230..313	CDD:197361	31/124 (25%)
Optn	XP_017455943.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D326045at33208
OrthoFinder	1	1.000	-	-		FOG0007215
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.880