DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment key and ikbkg

DIOPT Version :9

Sequence 1:	NP_001246503.1	Gene:	key / 37967	FlyBaseID:	FBgn0041205	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	XP_012816058.1	Gene:	ikbkg / 100145270	XenbaseID:	XB-GENE-979184	Length:	553	Species:	Xenopus tropicalis

Alignment Length:	446	Identity:	99/446 - (22%)
Similarity:	164/446 - (36%)	Gaps:	113/446 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DEESFVILGSSPCSSLMPDSSLRSDVCGNAQEAKETVASTSTQPPTVNCIPVSITASQQQHK--- 64
            :|:.:    ::|.|||....:|...:|       ||:..|         :|.....|:.:.|
Frog   158 EEQDY----ATPGSSLSSCETLTHSIC-------ETIRQT---------VPDEEGPSRNKQKENG 202

  Fly    65 --------SLDSGSSQQQSLATSFIMGEIQSDVLKNSVYSQFPSLCSLQGSAEEVVKLQNMMTEY 121
                    .:..|:..:.|........::|....:|:.:.:  .:..||   |||.||:..:.|
Frog   203 NKEVCMENEIMQGTVDRNSRTEQEFQKKLQDAEARNTQFLR--QIADLQ---EEVSKLRRQVVE- 261

  Fly   122 LALKSTLDKVNQTMLNYHNLTQQWRQEAADREHQYKEHV-------KECQAQIAILRVENQELKR 179
                    |..::.....:|..|..|.:.:| :..|..|       ||.|..:.|...|.::::.
Frog   262 --------KGEESQKQLQSLQLQMEQLSEER-NSVKAQVTSLLGELKESQTSLEICLQEKRKVED 317

  Fly   180 DLETKIEQIEGVHTIRLKEQ----DELRKSVS--------EKQSLIDNMRVEIDKLKQLNHSFE- 231
            .|.:.:|:.:|... ::|:|    |:....|.        |:|:..|..|    ||.||..::.
Frog   318 SLRSALEEKKGWEA-QVKQQVVQLDQRMMQVQNLETALKMERQNATDEKR----KLAQLQVAYHT 377

  Fly   232 FVPEYATESK----SQELIKKMQLDINELKAR--------------------DIQKQ----EVIK 268
            ...||.|..|    ..:..|.:.|.|.|||.:                    :.:||    :.:.
Frog   378 LFQEYDTHIKVSMQQAKHTKGVDLQIQELKQQLQEAEEALVAKQALIDKLKDEAEKQRTELDTVP 442

  Fly   269 GLQIQNDIYRRDFEMERADREKNAGEKDQYLMDLR-SLQRR--NQELIEALAESHKASKACSTAS 330
            .|:.|.:|||.||..||..||:...||::....|. .||.|  |:.:|:.:...|.     .|..
Frog   443 VLKAQVEIYRADFLAERKAREELHAEKERLQEQLNVLLQERLSNRAMIDEMRNRHS-----DTLR 502

  Fly   331 PLSSSRSNLREEQRPVRILDPTGASSRTSDTTLRCPICSKSFNALSVLQSHVNDCL 386
            |......:|...| |.....|     ........||.|......:..||.||.||:
Frog   503 PTLPHGPSLYPLQ-PAMPFQP-----EVEPPDFSCPKCFYKAPDMDTLQIHVMDCI 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
key	NP_001246503.1	DUF499	<168..>351	CDD:303008	54/226 (24%)
key	NP_001246503.1	UBAN	230..313	CDD:197361	30/114 (26%)
ikbkg	XP_012816058.1	NEMO	42..108	CDD:371612
		SMC_prok_B	82..>371	CDD:274008	50/252 (20%)
		SMC_prok_A	229..>500	CDD:274009	69/295 (23%)
		UBAN	402..483	CDD:197361	22/80 (28%)
		zf_C2H2_10	527..552	CDD:375840	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	61	1.000	Inparanoid score	I5214
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D326045at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.970