DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment key and optn

DIOPT Version :9

Sequence 1:	NP_001246503.1	Gene:	key / 37967	FlyBaseID:	FBgn0041205	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	XP_017947825.1	Gene:	optn / 100144665	XenbaseID:	XB-GENE-943658	Length:	538	Species:	Xenopus tropicalis

Alignment Length:	431	Identity:	97/431 - (22%)
Similarity:	176/431 - (40%)	Gaps:	93/431 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSDEESFVILGSSPCSSLMPDSSLRSDVC-GNAQEAKETVASTSTQPPTVNCIPVSITASQQQHK 64
            :|::||..|:.....:..:||    .||. ......||..:.|..:...::.:..|:....|:.:
Frog   155 ISEKESGEIIHEEKANKTLPD----YDVSYSRTNSVKEEGSGTEPEEVAISRLLRSLREETQKVE 215

  Fly    65 SLDSGSSQQQSLA------TSFIMGEIQSDVLKNSVYSQFPSLCSLQGSAEEVVKLQ---NMMTE 120
            .|:...|:.:.||      :.|...::|::..|             |..:||:..|.   .:.:|
Frog   216 RLEKELSEHKRLAELKEKTSRFCDKDMQTEQEK-------------QNQSEEIFLLHAFFQISSE 267

  Fly   121 YLALKSTLDKVNQTMLNYHNLTQQWRQEAADREHQYKEHVKECQAQIAILRVENQELKRDLETK- 184
            ...||..:..:|:.:           ||..|:.::.|:.....|.:..:|....||...|||.|
Frog   268 VDILKQKVKSLNKEL-----------QETNDKLNEAKQLKNSLQEKCILLDKRLQENAVDLEEKQ 321

  Fly   185 -----IEQIE-GVHTIRLKEQDELRKSVSEKQSLIDNMRVEIDKLKQLNHSFEFV----PEYATE 239
                 |:::| .|.::..:.:.|..|:.:||..|. .::|..||   ||..::..    .|..::
Frog   322 NLRYTIKKLELQVESMESEIKLERNKTEAEKNQLA-ILQVAYDK---LNSEYQETRIRESEKVSK 382

  Fly   240 SKSQELIKKM----------QLDINELKARDIQKQEVIKG---LQIQNDIYRRDFEMERADREKN 291
            .:..:|::|:          |.:|:|::..|.:.:|.|:.   |:.|.|:|..||..||:.||..
Frog   383 VEFNDLVEKLDACEKALAKKQFEIDEIRQMDAKHKEDIETIGLLRAQIDVYCADFHAERSARENI 447

  Fly   292 AGEKDQYLMDLRSLQRRNQEL---------IEALAESHKASKACSTASPLSSSRSNLREEQRPVR 347
            ..||:|....|..:.:.:::|         ||.|...|.......:..|
Frog   448 HQEKEQLEARLAYMIQESEKLKAEMMGRQSIEQLQRRHSCRLENVSGGP---------------- 496

  Fly   348 ILDPTGASS--RTSDTTLRCPICSKSFNALSVLQSHVNDCL 386
            .|.|.||.:  :.|.|...||.|:.:...:..||.||.||:
Frog   497 YLVPRGAENMGQPSITVYTCPKCNLTVPDIDTLQIHVMDCI 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
key	NP_001246503.1	DUF499	<168..>351	CDD:303008	50/215 (23%)
key	NP_001246503.1	UBAN	230..313	CDD:197361	24/108 (22%)
optn	XP_017947825.1	NEMO	31..97	CDD:371612
		SMC_prok_B	<194..>412	CDD:274008	48/245 (20%)
		CC2-LZ	370..469	CDD:374596	23/98 (23%)
		zf_C2H2_10	514..537	CDD:375840	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	61	1.000	Inparanoid score	I5214
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D326045at33208
OrthoFinder	1	1.000	-	-		FOG0007215
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.060