DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3589 and HTRA3

DIOPT Version :9

Sequence 1:NP_611968.1 Gene:CG3589 / 37966 FlyBaseID:FBgn0035065 Length:509 Species:Drosophila melanogaster
Sequence 2:NP_444272.1 Gene:HTRA3 / 94031 HGNCID:30406 Length:453 Species:Homo sapiens


Alignment Length:218 Identity:58/218 - (26%)
Similarity:87/218 - (39%) Gaps:55/218 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   318 ILTCAHVVGQNIETVNCRAADREFQSEVIWCNPDS--------DKPFDLALLTA-PQDVPEQCCV 373
            |:|.||||..|      .||....|.:|...|.||        ||..|:|.:.. |:   ::..|
Human   186 IITNAHVVSSN------SAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPK---KKLPV 241

  Fly   374 RLARSPATV--GQMVYNAGFPYYVNFSFRHDFNPSIF-----QGRVI---KCDTGAIMSDGSVQA 428
            .|....|.:  |:.|...|.|    |:.::.....|.     :||.:   ..|...|.:|..:..
Human   242 LLLGHSADLRPGEFVVAIGSP----FALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINY 302

  Fly   429 GQSGGPMFDQNGCILGVCVSNIKLDDVVYPNINTAIPICDIRNTLQQF----------------A 477
            |.||||:.:.:|.::|  ::.:|    |...|:.|||...|...|.:|                .
Human   303 GNSGGPLVNLDGEVIG--INTLK----VTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRM 361

  Fly   478 RTNDLNVLSNLVAS-PDVHRVWS 499
            ||...:::..|.|| ||...|.|
Human   362 RTITPSLVDELKASNPDFPEVSS 384

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3589NP_611968.1 Trypsin 296..471 CDD:278516 47/171 (27%)
Trypsin_2 305..445 CDD:290102 39/145 (27%)
HTRA3NP_444272.1 IGFBP 25..76 CDD:278641
Kazal_2 81..126 CDD:284958
Serine protease 175..340 47/172 (27%)
Trypsin_2 175..319 CDD:290102 40/147 (27%)
PDZ_serine_protease 355..440 CDD:238487 9/30 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0265
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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