DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3589 and Htra3

DIOPT Version :9

Sequence 1:	NP_611968.1	Gene:	CG3589 / 37966	FlyBaseID:	FBgn0035065	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_006504249.1	Gene:	Htra3 / 78558	MGIID:	1925808	Length:	467	Species:	Mus musculus

Alignment Length:	180	Identity:	44/180 - (24%)
Similarity:	74/180 - (41%)	Gaps:	42/180 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 ILTCAHVVGQN----------IETVNCRAADREFQSEVIWCNPDSDKPFDLA-LLTAPQDVPEQC 371
            |:|.||||..:          ::..|..|.:...|        |.||..|:| ::..|:   ::.
Mouse   192 IVTNAHVVSSSSTASGRQQLKVQLQNGDAYEATIQ--------DIDKKSDIATIVIHPK---KKL 245

  Fly   372 CVRLARSPATV--GQMVYNAGFPYYVNFSFRHDFNPSIF-----QGRVI---KCDTGAIMSDGSV 426
            .|.|....|.:  |:.|...|.|    |:.::.....|.     .|:.:   ..|...|.:|..:
Mouse   246 PVLLLGHSADLRPGEFVVAIGSP----FALQNTVTTGIVSTAQRDGKELGLRDSDMDYIQTDAII 306

  Fly   427 QAGQSGGPMFDQNGCILGVCVSNIKLDDVVYPNINTAIPICDIRNTLQQF 476
            ..|.||||:.:.:|.::|  ::.:|    |...|:.|||...|...|.:|
Mouse   307 NYGNSGGPLVNLDGEVIG--INTLK----VAAGISFAIPSDRITRFLSEF 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3589	NP_611968.1	Trypsin	296..471	CDD:278516	42/173 (24%)
CG3589	NP_611968.1	Trypsin_2	305..445	CDD:290102	34/147 (23%)
Htra3	XP_006504249.1	IGFBP	31..82	CDD:365955
		Kazal_2	<95..132	CDD:369449
		degP_htrA_DO	149..>440	CDD:273938	44/180 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810