DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3589 and htra1

DIOPT Version :9

Sequence 1:	NP_611968.1	Gene:	CG3589 / 37966	FlyBaseID:	FBgn0035065	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001072730.2	Gene:	htra1 / 780187	XenbaseID:	XB-GENE-487699	Length:	460	Species:	Xenopus tropicalis

Alignment Length:	188	Identity:	52/188 - (27%)
Similarity:	80/188 - (42%)	Gaps:	30/188 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 ESAGQQGTGTFIRVHNKRFILTCAHVVGQNIETVNCRAADREFQSEVIWCNPDSDKPFDLAL--L 361
            |.....|:| || |.....|||.||||.........|:....:.:::|    |.|:..|:||  :
Frog   177 EVPAASGSG-FI-VSEDGLILTNAHVVTNKHRLKVERSDGSTYDAQII----DVDEKADIALIKI 235

  Fly   362 TAPQDVPEQCCVRLARS-PATVGQMVYNAGFPYYVNFSFRHDFNPSIFQ-----GRVI---KCDT 417
            .|...:|   .:.|.|| ....|:.|...|.|    ||.::.....|..     |:.:   ..|.
Frog   236 KAKGKLP---VLLLGRSEDLRPGEFVVAIGSP----FSLQNTVTTGIVSTAQRGGKELGLRNSDM 293

  Fly   418 GAIMSDGSVQAGQSGGPMFDQNGCILGVCVSNIKLDDVVYPNINTAIPICDIRNTLQQ 475
            ..|.:|..:..|.||||:.:.:|.::|  ::.:|    |...|:.|||...||..|.:
Frog   294 DYIQTDAIINYGNSGGPLVNLDGEVIG--INTLK----VTAGISFAIPSDKIRKFLAE 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3589	NP_611968.1	Trypsin	296..471	CDD:278516	50/182 (27%)
CG3589	NP_611968.1	Trypsin_2	305..445	CDD:290102	41/150 (27%)
htra1	NP_001072730.2	IGFBP	26..80	CDD:365955
		KAZAL	89..>115	CDD:197624
		degP_htrA_DO	151..>459	CDD:273938	52/188 (28%)
		Serine protease	183..343		50/178 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910