DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3589 and Tysnd1

DIOPT Version :9

Sequence 1:	NP_611968.1	Gene:	CG3589 / 37966	FlyBaseID:	FBgn0035065	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_082188.1	Gene:	Tysnd1 / 71767	MGIID:	1919017	Length:	568	Species:	Mus musculus

Alignment Length:	485	Identity:	124/485 - (25%)
Similarity:	203/485 - (41%)	Gaps:	99/485 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 PQQRRPRPIAAPGSRQPHIL---SRFTAHPLYVFCANEVCRNLHHILLTADSGDAGEVLRSSFVV 149
            |.:.|.||:..|...|..:|   ..|.:|...:|.|:.|  :..|.:.:|......|
Mouse   120 PSRARARPLQPPRPAQLLLLLSCPAFRSHFARLFGADAV--DQWHFVSSAPDDAVSE-------- 174

  Fly   150 LGLRKPEKEKSFKRFLAHIANYLRYLQ---------PMHTLDDV--------LVMC-SPFGL--- 193
                  |:|:...|.|...| .||..:         |:.|:..:        |:.| ||||.
Mouse   175 ------EEEEDQLRALGWFA-LLRVQRGAAAEERRGPVVTVAPLGAVVKGAPLLACGSPFGAFCP 232

  Fly   194 ENFYKTISIGKVSNVMGRSGCLFAISNALPLGCEGSAVFNNKL--RLVGIVICTSFQRHHENVNL 256
            :.|..|:|.|.:||..|  ..|...:..|| |.||..||..:.  .||.:|......:..|.|.|
Mouse   233 DIFLNTLSRGVLSNAAG--PLLLTDARCLP-GTEGGGVFAARPAGALVALVAAPLCWKAREWVGL 294

  Fly   257 TL---AANFGYLLRNFMEQLGMSTTAFQLSREPSSFA-------------WERTIVVIESAGQQG 305
            ||   ||....:.|..:.:|...:.:..:...|...:             |....|::|.....|
Mouse   295 TLLCAAAPLLQVARWALARLHPGSASLSVLLPPPDVSTPRGLPLRDLGPPWAAAAVLVECGTVWG 359

  Fly   306 TGTFIRVHNKRFILTCAHVVGQNIETVNCRAADRE---FQSEVIWCNPDSDKPFDLALLTAPQD- 366
            :|..:.   .|.::||.||..:....|...:|..:   ...:|::...:: .|:|:|:::..::
Mouse   360 SGVVVA---PRLVVTCRHVAPREAARVLVHSATPKNVAIWGQVVFATQET-SPYDIAVVSLEEEL 420

  Fly   367 --VPEQCCVRLARSPATVGQMVYNAGFPY-YVNFS-FRHDFNPSIFQG---RVIKCDTGAIM--S 422
              ||         :|...|.  ::.|.|. .|.|. |.....||:..|   .|::.|...:|  :
Mouse   421 NGVP---------TPVPAGH--FHEGEPVSVVGFGVFGQACGPSVTSGILSAVVRVDGSPVMLQT 474

  Fly   423 DGSVQAGQSGGPMFDQ-NGCILGVCVSNIKLDD--VVYPNINTAIPICDIRNTLQQFARTNDLNV 484
            ..:|..|.||||:|.. :|.:||:..||.:.::  ..||::|.:|||..::..|:|:::|.||..
Mouse   475 TCAVHGGSSGGPLFSSGSGDLLGIVASNTRDNNTGATYPHLNFSIPITVLQPALKQYSQTGDLGG 539

  Fly   485 LSNLVASPD-VHRVWSLEMP----PIRSKL 509
            |..|..:.: |..||.|:.|    | ||||
Mouse   540 LRELDHTTEPVRVVWRLQRPLSEVP-RSKL 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3589	NP_611968.1	Trypsin	296..471	CDD:278516	48/190 (25%)
CG3589	NP_611968.1	Trypsin_2	305..445	CDD:290102	37/153 (24%)
Tysnd1	NP_082188.1	Tryp_SPc	<187..268	CDD:304450	24/84 (29%)
		Trypsin	344..528	CDD:278516	49/198 (25%)
		Trypsin_2	359..498	CDD:290102	37/153 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848598
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	77	1.000	Inparanoid score	I5239
Isobase	1	0.950	-	0	Normalized mean entropy	S8268
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006946
OrthoInspector	1	1.000	-	-		oto95392
orthoMCL	1	0.900	-	-		OOG6_107192
Panther	1	1.100	-	-	LDO	PTHR21004
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5783
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.730