DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3589 and htra3b

DIOPT Version :9

Sequence 1:	NP_611968.1	Gene:	CG3589 / 37966	FlyBaseID:	FBgn0035065	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_021333811.1	Gene:	htra3b / 573378	ZFINID:	ZDB-GENE-110602-1	Length:	466	Species:	Danio rerio

Alignment Length:	216	Identity:	49/216 - (22%)
Similarity:	89/216 - (41%)	Gaps:	34/216 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 NFGYLLRNFMEQLGMSTTAFQLSREPSSFAWERTIVVIESAGQQGTGTFIRVHNKRFILTCAHVV 325
            ||   :.:.:|::..:....:|......|.  ||:.:...:|...:.|.:.|.|...:.:...|.
Zfish   150 NF---IADVVEKIAPAVVHIELFLNHPLFG--RTVPLSSGSGFVMSETGLIVTNAHVVSSTTSVS 209

  Fly   326 GQNIETVNCRAADREFQSEVIWCNPDSDKPFDLALLTA-PQDVPEQCCVRLARSPATV--GQMVY 387
            |.....|..|..| .:::.:    .|.||..|:|.:.. ||   ::..|.|....|.:  |:.|.
Zfish   210 GHQRLKVQMRDGD-VYEATI----QDIDKKSDIATIKINPQ---KKLPVLLLGHSADLRPGEFVV 266

  Fly   388 NAGFPYYVNFSFRHDFNPSIF-----QGRVI---KCDTGAIMSDGSVQAGQSGGPMFDQNGCILG 444
            ..|.|    |:.::.....|.     .|:.:   ..|...|.:|..:..|.||||:.:.:|.::|
Zfish   267 AIGSP----FALQNTVTTGIVSTAQRDGKELGLQDSDMDYIQTDAIINYGNSGGPLVNLDGEVIG 327

  Fly   445 VCVSNIKLDDVVYPNINTAIP 465
              ::.:|    |...|:.|||
Zfish   328 --INTLK----VAAGISFAIP 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3589	NP_611968.1	Trypsin	296..471	CDD:278516	42/181 (23%)
CG3589	NP_611968.1	Trypsin_2	305..445	CDD:290102	34/150 (23%)
htra3b	XP_021333811.1	IGFBP	24..75	CDD:306685
		KAZAL	87..133	CDD:197624
		DegQ	152..>438	CDD:333159	47/211 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810