DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3589 and HTRA1

DIOPT Version :9

Sequence 1:	NP_611968.1	Gene:	CG3589 / 37966	FlyBaseID:	FBgn0035065	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_002766.1	Gene:	HTRA1 / 5654	HGNCID:	9476	Length:	480	Species:	Homo sapiens

Alignment Length:	319	Identity:	67/319 - (21%)
Similarity:	115/319 - (36%)	Gaps:	92/319 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 CLFAISNALPLGCEGSAVFNNKLRLVGIVICTSFQ--------------------RHHENV---- 254
            |...:...:|.|...||....:.: .|:.:|.|.:                    |..|.:
Human    83 CGEGLQCVVPFGVPASATVRRRAQ-AGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPP 146

  Fly   255 -----------------NLTLAANFGYLLRNFMEQLGMSTTAFQLSRE-PSSFAWERTIVVIESA 301
                             :|....||   :.:.:|::..:....:|.|: |.|   :|.:.|...:
Human   147 VIVLQRGACGQGQEDPNSLRHKYNF---IADVVEKIAPAVVHIELFRKLPFS---KREVPVASGS 205

  Fly   302 GQQGTGTFIRVHNKRFILTCAHVVGQ----NIETVNCRAADREFQSEVIWCNPDSDKPFDLALLT 362
            |      || |.....|:|.||||..    .:|..|....:.:.:        |.|:..|:||:.
Human   206 G------FI-VSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIK--------DVDEKADIALIK 255

  Fly   363 APQD--VPEQCCVRLAR-SPATVGQMVYNAGFPYYVNFSFRHDFNPSIFQ-----GRVI---KCD 416
            ....  :|   .:.|.| |....|:.|...|.|    ||.::.....|..     |:.:   ..|
Human   256 IDHQGKLP---VLLLGRSSELRPGEFVVAIGSP----FSLQNTVTTGIVSTTQRGGKELGLRNSD 313

  Fly   417 TGAIMSDGSVQAGQSGGPMFDQNGCILGVCVSNIKLDDVVYPNINTAIPICDIRNTLQQ 475
            ...|.:|..:..|.||||:.:.:|.::|  ::.:|    |...|:.|||...|:..|.:
Human   314 MDYIQTDAIINYGNSGGPLVNLDGEVIG--INTLK----VTAGISFAIPSDKIKKFLTE 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3589	NP_611968.1	Trypsin	296..471	CDD:278516	47/189 (25%)
CG3589	NP_611968.1	Trypsin_2	305..445	CDD:290102	37/154 (24%)
HTRA1	NP_002766.1	IB	35..111	CDD:197525	6/28 (21%)
		KAZAL	115..155	CDD:197624	2/39 (5%)
		DegQ	154..480	CDD:223343	57/247 (23%)
		Serine protease	204..364		46/187 (25%)
		Trypsin_2	204..342	CDD:290102	39/161 (24%)
		PDZ_serine_protease	382..473	CDD:238487
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810