Protein Alignment CG3589 and HTRA1

DIOPT Version :10

• Sequence 1: NP_611968.1
• Gene: CG3589 / 37966
• FlyBaseID: FBgn0035065
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_002766.1
• Gene: HTRA1 / 5654
• HGNCID: 9476
• Length: 480
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 67/319 - (21%)
• Similarity: 115/319 - (36%)
• Gaps: 92/319 - (28%)

  Fly   214 CLFAISNALPLGCEGSAVFNNKLRLVGIVICTSFQ--------------------RHHENV---- 254
            |...:...:|.|...||....:.: .|:.:|.|.:                    |..|.:
Human    83 CGEGLQCVVPFGVPASATVRRRAQ-AGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPP 146

  Fly   255 -----------------NLTLAANFGYLLRNFMEQLGMSTTAFQLSRE-PSSFAWERTIVVIESA 301
                             :|....||   :.:.:|::..:....:|.|: |.|   :|.:.|...:
Human   147 VIVLQRGACGQGQEDPNSLRHKYNF---IADVVEKIAPAVVHIELFRKLPFS---KREVPVASGS 205

  Fly   302 GQQGTGTFIRVHNKRFILTCAHVVGQ----NIETVNCRAADREFQSEVIWCNPDSDKPFDLALLT 362
            |      || |.....|:|.||||..    .:|..|....:.:.:        |.|:..|:||:.
Human   206 G------FI-VSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIK--------DVDEKADIALIK 255

  Fly   363 APQD--VPEQCCVRLAR-SPATVGQMVYNAGFPYYVNFSFRHDFNPSIFQ-----GRVI---KCD 416
            ....  :|   .:.|.| |....|:.|...|.|    ||.::.....|..     |:.:   ..|
Human   256 IDHQGKLP---VLLLGRSSELRPGEFVVAIGSP----FSLQNTVTTGIVSTTQRGGKELGLRNSD 313

  Fly   417 TGAIMSDGSVQAGQSGGPMFDQNGCILGVCVSNIKLDDVVYPNINTAIPICDIRNTLQQ 475
            ...|.:|..:..|.||||:.:.:|.::|  ::.:|    |...|:.|||...|:..|.:
Human   314 MDYIQTDAIINYGNSGGPLVNLDGEVIG--INTLK----VTAGISFAIPSDKIKKFLTE 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3589	NP_611968.1	Trypsin_2	305..445	CDD:433149	37/154 (24%)
HTRA1	NP_002766.1	IB	35..111	CDD:197525	6/28 (21%)
		KAZAL	115..155	CDD:197624	2/39 (5%)
		DegQ	202..477	CDD:440035	47/193 (24%)
		Serine protease	204..364		46/187 (25%)