DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3589 and HtrA2

DIOPT Version :9

Sequence 1:	NP_611968.1	Gene:	CG3589 / 37966	FlyBaseID:	FBgn0035065	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	90/403 - (22%)
Similarity:	150/403 - (37%)	Gaps:	118/403 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 IAAPGS-RQPHILSRFTAHP-LYVFCANEVCRNLHHILLTAD---SGDAGEVLRSSFVVLGLRKP 155
            :|..|| |...|..|..|.| |:...||.  |:....:...|   :|::|:..::.        .
  Fly     1 MALRGSHRLEVIFKRCIASPVLHSHAANR--RSSQLAIKEGDPNSNGNSGQYQQNG--------E 55

  Fly   156 EKEKSFKRFLAHIANYLRYLQPMHTLDDVLVMCSPFGLENFYKTISIGKVSNVMGRSGCLFAISN 220
            :|||.::|.       :|:..|...  ..:|..:....|:...||:..|::   ||......|::
  Fly    56 QKEKGWRRL-------VRFFVPFSL--GAVVSAAIIQREDLTPTIAASKMT---GRRRDFNFIAD 108

  Fly   221 ALPLGCEGSAVFNNKLRLVGIVICTSFQRHHENVNLTLAANFGYLLRNFMEQLGMSTTAFQLSRE 285
            .: .||..|.|:                     :.:....:|.|.       .|...||
  Fly   109 VV-AGCADSVVY---------------------IEIKDTRHFDYF-------SGQPITA------ 138

  Fly   286 PSSFAWERTIVVIESAGQQGTGTFIRVHNKRFILTCAHVVGQNIET-VNCRAAD-REFQSEVIWC 348
                             ..|:| || :.....|||.||||.....| |..|.:| |.|.:.:
  Fly   139 -----------------SNGSG-FI-IEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATI--- 181

  Fly   349 NPDSDKPFDLALLTAPQDVPEQCCVRLARSPATV--GQMVYNAGFPYYVNFSFRHDFNPSIFQGR 411
             .|.|:..|||.|..  .|.....:||.:| :|:  |:.|...|.|..:        :.::..|.
  Fly   182 -EDVDQTSDLATLRI--QVNNLSVMRLGKS-STLRSGEWVVALGSPLAL--------SNTVTAGV 234

  Fly   412 VIKC------------DTGAIMSDGSVQAGQSGGPMFDQNGCILGVCVSNIKLDDVVYPNINTAI 464
            :...            |...:.:|.::..|.||||:.:.:|..:|  |:::|    |...|:.||
  Fly   235 ISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIG--VNSMK----VTAGISFAI 293

  Fly   465 PICDIRNTLQQFA 477
            ||..::..|::.|
  Fly   294 PIDYVKVFLERAA 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3589	NP_611968.1	Trypsin	296..471	CDD:278516	50/190 (26%)
CG3589	NP_611968.1	Trypsin_2	305..445	CDD:290102	41/155 (26%)
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	70/320 (22%)
		Trypsin_2	141..280	CDD:290102	42/157 (27%)
		PDZ_serine_protease	323..417	CDD:238487
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810