DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3589 and Htra3

DIOPT Version :9

Sequence 1:	NP_611968.1	Gene:	CG3589 / 37966	FlyBaseID:	FBgn0035065	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001257956.1	Gene:	Htra3 / 360959	RGDID:	1308120	Length:	459	Species:	Rattus norvegicus

Alignment Length:	220	Identity:	53/220 - (24%)
Similarity:	85/220 - (38%)	Gaps:	59/220 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 ILTCAHVVGQN----------IETVNCRAADREFQSEVIWCNPDSDKPFDLA-LLTAPQDVPEQC 371
            |:|.||||..:          ::..|..|.:...|        |.||..|:| :|..|.   ::.
  Rat   192 IVTNAHVVSSSNTASGRQQLKVQLQNGDAYEATIQ--------DIDKKSDIATILIHPN---KKL 245

  Fly   372 CVRLARSPATV--GQMVYNAGFPYYVNFSFRHDFNPSIF-----QGRVI---KCDTGAIMSDGSV 426
            .|.|....|.:  |:.|...|.|    |:.::.....|.     .|:.:   ..|...|.:|..:
  Rat   246 PVLLLGHSADLRPGEFVVAIGSP----FALQNTVTTGIVSTAQRDGKELGLRDSDMDYIQTDAII 306

  Fly   427 QAGQSGGPMFDQNGCILGVCVSNIKLDDVVYPNINTAIPICDIRNTLQQF--------------- 476
            ..|.||||:.:.:|.::|  ::.:|    |...|:.|||...|...|.:|
  Rat   307 NYGNSGGPLVNLDGEVIG--INTLK----VAAGISFAIPSDRITRFLSEFQDKHVKDWKKRFIGI 365

  Fly   477 -ARTNDLNVLSNL-VASPDVHRVWS 499
             .||...:::..| .|:||...|.|
  Rat   366 RMRTITPSLVEELKTANPDFPAVSS 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3589	NP_611968.1	Trypsin	296..471	CDD:278516	43/173 (25%)
CG3589	NP_611968.1	Trypsin_2	305..445	CDD:290102	35/147 (24%)
Htra3	NP_001257956.1	IGFBP	31..82	CDD:278641
		Kazal_2	87..132	CDD:284958
		Serine protease. /evidence=ECO:0000250	181..346		43/174 (25%)
		Trypsin_2	181..325	CDD:290102	36/149 (24%)
		PDZ_serine_protease	361..446	CDD:238487	8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810