DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3589 and Htra2

DIOPT Version :9

Sequence 1:	NP_611968.1	Gene:	CG3589 / 37966	FlyBaseID:	FBgn0035065	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001100069.1	Gene:	Htra2 / 297376	RGDID:	1308906	Length:	458	Species:	Rattus norvegicus

Alignment Length:	224	Identity:	58/224 - (25%)
Similarity:	87/224 - (38%)	Gaps:	66/224 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 LSREPSSFAWERTIVVIESAGQQGTGTFIRVHNKRFILTCAHVVGQNIETVNCRAADREFQSEVI 346
            |.|.|.|   .|.:.:...:|      || |.:...|:|.||||           |||.   .|.
  Rat   167 LDRHPFS---GREVPISNGSG------FI-VASDGLIVTNAHVV-----------ADRR---RVR 207

  Fly   347 WCNPDSDKPFDLALLTAPQDVPEQCCVR-----------LARSPATV--GQMVYNAGFPYYVNFS 398
            ...|..| .:: |::||...|.:...:|           |.|| |.|  |:.|...|.|:.:
  Rat   208 VRLPSGD-TYE-AMVTAVDPVADIATLRIQTKEPLPTLPLGRS-ADVRQGEFVVAMGSPFAL--- 266

  Fly   399 FRHDFNPSIFQGRVIKCDTGA------------IMSDGSVQAGQSGGPMFDQNGCILGVCVSNIK 451
                 ..:|..|.|......|            |.:|.::..|.||||:.:.:|.::|  |:.:|
  Rat   267 -----QNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIG--VNTMK 324

  Fly   452 LDDVVYPNINTAIPICDIRNTLQQFARTN 480
                |...|:.|||...:|..|.:..:.|
  Rat   325 ----VTAGISFAIPSDRLREFLHRGEKKN 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3589	NP_611968.1	Trypsin	296..471	CDD:278516	50/199 (25%)
CG3589	NP_611968.1	Trypsin_2	305..445	CDD:290102	41/164 (25%)
Htra2	NP_001100069.1	DegQ	140..454	CDD:223343	58/224 (26%)
		Trypsin_2	182..320	CDD:290102	43/171 (25%)
		PDZ_serine_protease	360..452	CDD:238487
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810