DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3589 and TYSND1

DIOPT Version :9

Sequence 1:	NP_611968.1	Gene:	CG3589 / 37966	FlyBaseID:	FBgn0035065	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_775826.2	Gene:	TYSND1 / 219743	HGNCID:	28531	Length:	566	Species:	Homo sapiens

Alignment Length:	491	Identity:	130/491 - (26%)
Similarity:	201/491 - (40%)	Gaps:	111/491 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 PQQRRPRPIAAPGSRQPHILSR---------FTAHPLYVFCANEVCRNLHHILLTAD----SGDA 139
            |...|.||:      ||.:.:.         |.||...:| .:|............|    ..:.
Human   118 PAPSRGRPL------QPRLPAELLLLLSCPAFWAHFARLF-GDEAAEQWRFSSAARDDEVSEDEE 175

  Fly   140 GEVLRSS--FVVLGLRKPEKEKSFKRFLAHIANYLRYLQPMHTLD---DVLVMCSPFGL---ENF 196
            .:.||:.  |.:||:|..::|...:|..|      ..:.|:..:.   .:||..||||.   :.|
Human   176 ADQLRALGWFALLGVRLGQEEVEEERGPA------MAVSPLGAVPKGAPLLVCGSPFGAFCPDIF 234

  Fly   197 YKTISIGKVSNVMGRSGCLFAISNALPLGCEGSAVFNNKL--RLVGIVICTSFQRHHENVNLTL- 258
            ..|:|.|.:|||.|  ..|...:..|| |.||..||..:.  .||.:|:.....:..|.|..||
Human   235 LNTLSCGVLSNVAG--PLLLTDARCLP-GTEGGGVFTARPAGALVALVVAPLCWKAGEWVGFTLL 296

  Fly   259 --AANFGYLLRNFMEQLGMSTTAFQLSREP------------SSFAWERTIVVIESAGQQGTGTF 309
              ||......|:.:.:|..||.|......|            |...|....|::|.....|:|..
Human   297 CAAAPLFRAARDALHRLPHSTAALAALLPPEVGVPWGLPLRDSGPLWAAAAVLVECGTVWGSGVA 361

  Fly   310 IRVHNKRFILTCAHVVGQNIETVNCRAADREFQSEVIW----------CNPDSDKPFDLALLTAP 364
            :.   .|.::||.||..:....|..|:...  :|..||          |      |:|:|:::..
Human   362 VA---PRLVVTCRHVSPREAARVLVRSTTP--KSVAIWGRVVFATQETC------PYDIAVVSLE 415

  Fly   365 QDVPEQCCVRLARSPATV-------GQMVYNAGFPYYVNFSFRHDFNPSIFQG---RVIKCDTGA 419
            :|:.:        .|..|       |:.|...||..     |.....||:..|   .|::.:...
Human   416 EDLDD--------VPIPVPAEHFHEGEAVSVVGFGV-----FGQSCGPSVTSGILSAVVQVNGTP 467

  Fly   420 IM--SDGSVQAGQSGGPMF-DQNGCILGVCVSNIKLDD--VVYPNINTAIPICDIRNTLQQFART 479
            :|  :..:|.:|.||||:| :.:|.:||:..||.:.::  ..||::|.:|||..::..|||:::|
Human   468 VMLQTTCAVHSGSSGGPLFSNHSGNLLGIITSNTRDNNTGATYPHLNFSIPITVLQPALQQYSQT 532

  Fly   480 NDLNVLSNL--VASPDVHRVWSLEMP----PIRSKL 509
            .||..|..|  .|.| |..||.|:.|    | ||||
Human   533 QDLGGLRELDRAAEP-VRVVWRLQRPLAEAP-RSKL 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3589	NP_611968.1	Trypsin	296..471	CDD:278516	49/199 (25%)
CG3589	NP_611968.1	Trypsin_2	305..445	CDD:290102	38/162 (23%)
TYSND1	NP_775826.2	Tryp_SPc	<185..278	CDD:304450	32/101 (32%)
		Trypsin	346..526	CDD:278516	49/203 (24%)
		Trypsin_2	357..496	CDD:290102	38/162 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158216
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I5130
Isobase	1	0.950	-	0	Normalized mean entropy	S8268
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1307240at2759
OrthoFinder	1	1.000	-	-		FOG0006946
OrthoInspector	1	1.000	-	-		oto91815
orthoMCL	1	0.900	-	-		OOG6_107192
Panther	1	1.100	-	-	LDO	PTHR21004
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5783
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.740