Protein Alignment CG3589 and HTRA4

DIOPT Version :9

• Sequence 1: NP_611968.1
• Gene: CG3589 / 37966
• FlyBaseID: FBgn0035065
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_710159.1
• Gene: HTRA4 / 203100
• HGNCID: 26909
• Length: 476
• Species: Homo sapiens
• Alignment Length: 399
• Identity: 87/399 - (21%)
• Similarity: 138/399 - (34%)
• Gaps: 133/399 - (33%)

  Fly   214 CLFAISNALP--LGCE--GSAVF----------------NNKLRLVGIVICTSFQRHHENVNLTL 258
            ||..:....|  .||.  |.||.                |...|.:|.|.....|  ..|...|.
Human    94 CLQPLRPGFPSTCGCPTLGGAVCGSDRRTYPSMCALRAENRAARRLGKVPAVPVQ--WGNCGDTG 156

  Fly   259 AANFGYLLRNF------MEQLGMSTTAFQLSREPSSFAWER-----TIVVIESAGQQGTGTFIRV 312
            ..:.|.|.||:      :|::..|....||        |.|     .:|.:.|    |:| || |
Human   157 TRSAGPLRRNYNFIAAVVEKVAPSVVHVQL--------WGRLLHGSRLVPVYS----GSG-FI-V 207

  Fly   313 HNKRFILTCAHVV--GQNIETVNCRAADREFQSEVIWCNPDSDKPFDLALLTAPQDVPEQCCVRL 375
            .....|:|.||||  .|.||.|....|  .:::.|    .|.|...|||::....:. |...:.|
Human   208 SEDGLIITNAHVVRNQQWIEVVLQNGA--RYEAVV----KDIDLKLDLAVIKIESNA-ELPVLML 265

  Fly   376 AR-SPATVGQMVYNAGFPYYVNFSFRHDFNPSIFQ-----GRVI---KCDTGAIMSDGSVQAGQS 431
            .| |....|:.|...|.|    ||.::.....|..     |:.:   ..|...:..|.::..|.|
Human   266 GRSSDLRAGEFVVALGSP----FSLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNS 326

  Fly   432 GGPMFDQNGCILGVCVSNIKLDDVV---------------------------------------- 456
            |||:.:.:|.::|  |:::::.|.:
Human   327 GGPLVNLDGDVIG--VNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLGLQMLSLT 389

  Fly   457 -------------YPNINTAIPICD-IRNTLQQFARTNDLNVLSNLVASP-----DVHRVW---S 499
                         :|::::.:.:|. :..|..|.:...|.:|:.|:...|     ||.:..   |
Human   390 VPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDS 454

  Fly   500 LEMPPIRSK 508
            |.|..:|.|
Human   455 LSMAVLRGK 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3589	NP_611968.1	Trypsin	296..471	CDD:278516	49/239 (21%)
		Trypsin_2	305..445	CDD:290102	42/150 (28%)
HTRA4	NP_710159.1	IGFBP	40..94	CDD:278641	87/399 (22%)
		Kazal_2	108..152	CDD:284958	9/45 (20%)
		DegQ	156..470	CDD:223343	72/335 (21%)
		Serine protease	202..362		45/174 (26%)
		Trypsin_2	202..340	CDD:290102	43/152 (28%)
		PDZ_serine_protease	380..470	CDD:238487	15/84 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810