DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3589 and tysnd1

DIOPT Version :9

Sequence 1:	NP_611968.1	Gene:	CG3589 / 37966	FlyBaseID:	FBgn0035065	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_002936002.1	Gene:	tysnd1 / 100379910	XenbaseID:	XB-GENE-972865	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	602	Identity:	144/602 - (23%)
Similarity:	243/602 - (40%)	Gaps:	147/602 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 HALLEVTSPPAAKQ------------SAIIINNE--LIISSGSILQPHLAVDGDKGAQNKAIVAR 57
            |.::|..:|....:            |.:|::..  |::..|:|..|.|..:.:..::|..:.
Frog    35 HYIVEKRNPSLYNKAPQTECDGQWSCSGVILDRSLALVLCHGAIFFPFLKNNENAFSKNNLLA-- 97

  Fly    58 LQRGQLLDVQNEEQEEDAQIR----SLHFVAT-----FDPQ--QRRPR----PIAAPGSRQPHIL 107
                       |:.|.|..|:    |||..::     .|.:  |:||.    |::.......|.|
Frog    98 -----------EDFESDLIIQVECPSLHGTSSDSKIKLDAEGLQQRPGLGLIPLSDEAGLPTHQL 151

  Fly   108 SRFTAHPLYVFCANEVCRNLHHILLTA---------DSGDAGEVLRSS-----FVVLGLRKPEKE 158
             .:.|..|.:....|.......:...|         :..:.||:.:..     |.:|.||.|..:
Frog   152 -LYQAQLLMLVPCPEFQMAFSRLFSKAEGWEFSSEEEKHEYGELQKDLSYLHWFALLKLRSPLSD 215

  Fly   159 KSFKRFLAHIANYLRYLQPMHTLDD--VLVMC-SPFGLENFY-----KTISIGKVSNVMG-RSGC 214
            :..|         :.:: |...|:.  .::.| ||||  :||     .:||.|.:||..| |:..
Frog   216 RHKK---------ITFV-PSSMLEKGCTVIACGSPFG--SFYPDIFLNSISKGIISNTAGDRNVV 268

  Fly   215 LFAISNALPLGCEGSAVF---NNKLRLVGIVICTSFQRHHENVNLTLAANFGYLLRNFMEQLGMS 276
            |...:..|| |.||..:|   .::|.||||::.....:.:|.|.||:|.:..::|.|.::.|.:
Frog   269 LLTDARCLP-GSEGGGIFAAERDRLCLVGIIVVPLCWKANEWVGLTVACSISHILENIIKSLSL- 331

  Fly   277 TTAFQ----LSREPSSFAWE-------------RTIVVIESAGQQGTGTFIRVHNKRFILTCAHV 324
            |.|.:    ::.:...|...             .::|:::|....|:|..:   |.:.:|||.||
Frog   332 TKALEENNIIATKVEGFCSSDLKRVHKLTKKQIASVVLVDSGQVWGSGVLV---NPKVVLTCRHV 393

  Fly   325 VGQNIE--TVNCRAADRE-FQ---SEVIWCNPDSDKPFDLALLTAPQDVP---------EQCCVR 374
            | :|..  ||..|....| ||   .:|::...:| .|:|:|::.....:|         |.|
Frog   394 V-RNASRVTVKIRHPTSEMFQVLSGQVVFSTKES-SPYDVAVVELKDSIPGIPEPVLASEYC--- 453

  Fly   375 LARSPATVGQMVYNAGFPYYVNFSFRHDFNPSIFQG---RVIKCDTGAIMSDGS--VQAGQSGGP 434
                   .|..|...|:.     :|.....||...|   .||......:|...|  |..|.||||
Frog   454 -------TGMDVLIWGYG-----AFGESCGPSATSGVLSSVISIGDVPVMLQTSCAVHGGSSGGP 506

  Fly   435 MFDQN-GCILGVCVSNIK--LDDVVYPNINTAIPICDIRNTLQQFARTNDLNVLSNL-VASPDVH 495
            :|..: |.:||:..||.:  .....||::|.:||:..:...||::....||.....| ..|..|.
Frog   507 VFSSHTGELLGIVASNTRDNTTGATYPHLNFSIPVIILEEALQRYKLCGDLRSFQELNNVSHAVR 571

  Fly   496 RVWSLEMPP---IRSKL 509
            .||.|:..|   ::|||
Frog   572 NVWRLQRIPEKVLQSKL 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3589	NP_611968.1	Trypsin	296..471	CDD:278516	54/197 (27%)
CG3589	NP_611968.1	Trypsin_2	305..445	CDD:290102	44/160 (28%)
tysnd1	XP_002936002.1	Trypsin_2	<204..297	CDD:379142	32/105 (30%)
tysnd1	XP_002936002.1	Trypsin_2	377..518	CDD:379142	44/160 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	61	1.000	Inparanoid score	I5217
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1307240at2759
OrthoFinder	1	1.000	-	-		FOG0006946
OrthoInspector	1	1.000	-	-		oto105569
Panther	1	1.100	-	-	LDO	PTHR21004
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5783
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.100