DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3589 and htra4

DIOPT Version :9

Sequence 1:	NP_611968.1	Gene:	CG3589 / 37966	FlyBaseID:	FBgn0035065	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_017211746.2	Gene:	htra4 / 100334257	ZFINID:	ZDB-GENE-131120-192	Length:	459	Species:	Danio rerio

Alignment Length:	238	Identity:	56/238 - (23%)
Similarity:	88/238 - (36%)	Gaps:	61/238 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 SREPSSFAWERTIV--VIESAG---------------------QQGTGTFIRVHNKRFILTCAHV 324
            ||.|||..::...:  |::...                     ..|:| || |....:|:|.|||
Zfish   139 SRNPSSMRYKFNFIADVVDKIAPAVVHLELFSRLPFSNQDVPVSSGSG-FI-VSEDGWIVTNAHV 201

  Fly   325 VGQ----NIETVNCRAADREFQSEVIWCNPDSDKPFDLALLTAPQDVPEQCCVRLARSPATVGQM 385
            :..    .:|..|....|...:        |.|:..|:||:....:......:....|....|:.
Zfish   202 LSNKQRIKVELKNGMLYDATIK--------DVDQKLDIALIKIDSETALPVLLLGRSSDLRPGEF 258

  Fly   386 VYNAGFPYYVNFSFRHDFNPSIFQ-----GRVI---KCDTGAIMSDGSVQAGQSGGPMFDQNGCI 442
            |...|.|    ||.::.....|..     |..:   ..|...|.:|..:..|.||||:.:.:|.:
Zfish   259 VVAVGSP----FSLQNTVTTGIISTTHRGGHELGLQNSDMEYIQTDAIINYGNSGGPLVNLDGDV 319

  Fly   443 LGVCVSNIKLDDVVYPNINTAIPICDIRNTL------QQFART 479
            :|  ::.:|    |.|.|:.|||...||..|      |:..||
Zfish   320 IG--INTLK----VTPGISFAIPSDRIRQFLADSYERQRKGRT 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3589	NP_611968.1	Trypsin	296..471	CDD:278516	46/209 (22%)
CG3589	NP_611968.1	Trypsin_2	305..445	CDD:290102	36/151 (24%)
htra4	XP_017211746.2	IGFBP	27..80	CDD:306685
		KAZAL_FS	92..135	CDD:238052
		DegQ	118..459	CDD:223343	56/238 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810