Protein Alignment TyrRS-m and Yars2

DIOPT Version :10

• Sequence 1: NP_611967.1
• Gene: TyrRS-m / 37965
• FlyBaseID: FBgn0035064
• Length: 464
• Species: Drosophila melanogaster
• Sequence 2: NP_937889.1
• Gene: Yars2 / 70120
• MGIID: 1917370
• Length: 472
• Species: Mus musculus
• Alignment Length: 471
• Identity: 217/471 - (46%)
• Similarity: 304/471 - (64%)
• Gaps: 15/471 - (3%)

  Fly     3 PLRRSLLKPLQDV--LRHSH--RQMSQKNLLELTDRGFFHGIFPDTAA-PRMKQLFTR-----GQ 57
            |:.|.|.:..|.:  ||.|.  |..::..|:....||.|...||::.. ..:.:||.|     ..
Mouse     4 PMLRRLCRVPQSLVWLRGSRAVRPGARGMLVAPRARGLFKEFFPESGTKTELPELFDRRRAGSSP 68

  Fly    58 QSIYAGFDPTADSLHVGNLLVIMGLIHCQRAGHRPIALVGGATGLIGDPSGRKTERNQLGETVIE 122
            |::|.|||||.||||||:||.::||.|.|||||..||||||:|.|:||||||...|..|....:.
Mouse    69 QTVYCGFDPTGDSLHVGHLLTLLGLFHFQRAGHNVIALVGGSTALLGDPSGRTKGREALSAECVR 133

  Fly   123 TNLKAIEQQLRRVFENHENCLWDSKKQKLPLAPLIIVNNADWYADLQLIDFVANMGRHFRMGSML 187
            .|..|:.:.|..:..||.....|.:    |.....:::||.|:.:..|:||:|.:|.|||||::|
Mouse   134 ANAHALRRGLEALAANHARLFADGR----PWGSFTVLDNAAWFQEQHLVDFLATVGGHFRMGTLL 194

  Fly   188 SRSSVQSRLESEDGMSFTEFTYQIFQAYDWLHLLRRHNCCFQMGGSDQTGNLMTGHELISRVERK 252
            ||.||||||:|.:|||..||.||:.||||:.:|.:.:.|..|:|||||.||:|:|:|.|.::..:
Mouse   195 SRLSVQSRLKSPEGMSLAEFFYQVLQAYDFYYLFQHYGCRVQLGGSDQLGNIMSGYEFIHKLTGE 259

  Fly   253 REVFGLTLPLVTTEEGDKFGKSAGNAVWLDGNKTSPFALYQFFLRMPDSEVEKLLKLFTFIPLPQ 317
             :|||:|:||:|:..|.|.||||||||||:..|||||.|||||:|..|..||:.||||||:|||:
Mouse   260 -DVFGITVPLITSTTGAKLGKSAGNAVWLNREKTSPFELYQFFVRQQDDSVERYLKLFTFLPLPE 323

  Fly   318 VEQLMREHTKEPEKRKAQTLLAEDVTLLVHGESGLKQAERVTNALYKGNVEGLAELNLSEIQQTF 382
            ::.:|:.|.||||||.||..||.:||.||||:.||..|:|.|.|||..::|.|..::..|:::.|
Mouse   324 IDHIMQLHVKEPEKRVAQKRLAAEVTKLVHGQEGLDSAKRCTQALYHSSIEALEVMSDQELKELF 388

  Fly   383 QGATMVNLLTEPGMSILELAMKAKCFPTETDAVRIINAGGFYVNQKRVQNIAEVLTTGVHILRNG 447
            :.|:...|:.:||.|:::...||...|......|:|..||..:|.::|.|...||..|.|||:||
Mouse   389 KEASFSELVLDPGTSVIDTCRKANAIPDGPRGYRMITEGGVSINHRQVTNPESVLVIGQHILKNG 453

  Fly   448 ISLLRVGKRNFYIVRW 463
            :|||::|||||||::|
Mouse   454 LSLLKIGKRNFYIIKW 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRS-m	NP_611967.1	TyrS	28..464	CDD:439932	209/442 (47%)
Yars2	NP_937889.1	TyrS	51..469	CDD:439932	202/422 (48%)
		'HIGH' region	77..86		7/8 (88%)
		'KMSKS' region	276..280		2/3 (67%)