DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TyrRS-m and yars2

DIOPT Version :9

Sequence 1:	NP_611967.1	Gene:	TyrRS-m / 37965	FlyBaseID:	FBgn0035064	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_001137392.1	Gene:	yars2 / 556702	ZFINID:	ZDB-GENE-030131-6268	Length:	474	Species:	Danio rerio

Alignment Length:	453	Identity:	223/453 - (49%)
Similarity:	306/453 - (67%)	Gaps:	11/453 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VLRHSHRQMSQKNLLELTDRGFFHGIFPDTAA-PRMKQLFTRGQQSIYAGFDPTADSLHVGNLLV 78
            :|.||....:...|..|.:||.....||:.|| ..:..|...|.||||.||||||||||.||||.
Zfish    26 LLFHSSASKTSSLLSSLHNRGLLKDSFPEVAAQAEIPDLLRSGPQSIYCGFDPTADSLHAGNLLA 90

  Fly    79 IMGLIHCQRAGHRPIALVGGATGLIGDPSGRKTERNQLGETVIETNLKAIEQQLRRVFENHENCL 143
            |:||:|.:.|||..|||:||||..|||||||:|||.:|....::.|.:.|.:.|.|:|.:||  |
Zfish    91 IIGLLHFRSAGHHIIALLGGATAQIGDPSGRQTERERLSPAAVQENARGILESLHRIFTHHE--L 153

  Fly   144 W---DSKKQKLPLAPLIIVNNADWYADLQLIDFVANMGRHFRMGSMLSRSSVQSRLESEDGMSFT 205
            :   ||.:    |..|.::||..||.|..|::|.:.:||.||||:||||.|||:||:|.:|||||
Zfish   154 YFCPDSSR----LGRLTVLNNRSWYKDYDLLEFFSEVGRSFRMGTMLSRHSVQTRLKSAEGMSFT 214

  Fly   206 EFTYQIFQAYDWLHLLRRHNCCFQMGGSDQTGNLMTGHELISRVERKREVFGLTLPLVTTEEGDK 270
            ||:||:|||:|:..|.:.|.|..|:||:||.||:|:|||.|.| :...||:|||:|||||..|||
Zfish   215 EFSYQLFQAFDFYQLHQLHGCRIQLGGTDQLGNIMSGHEFIHR-KTGEEVYGLTVPLVTTSMGDK 278

  Fly   271 FGKSAGNAVWLDGNKTSPFALYQFFLRMPDSEVEKLLKLFTFIPLPQVEQLMREHTKEPEKRKAQ 335
            .||:|||||||:.:|||||..||:|||:||:.||:.||||||:.|.:||.||.:..|:|.||.|.
Zfish   279 LGKTAGNAVWLNRDKTSPFEFYQYFLRLPDNSVERYLKLFTFLSLSEVENLMEQQRKDPGKRIAH 343

  Fly   336 TLLAEDVTLLVHGESGLKQAERVTNALYKGNVEGLAELNLSEIQQTFQGATMVNLLTEPGMSILE 400
            ..||.:||.||||:.||:.|:|.|.|||..::|.|.:::.:|:|:.|:.|.......|||.::|:
Zfish   344 KRLAAEVTKLVHGKDGLESAKRCTTALYHSSIEALEQMSDTELQEIFREAPFHEFFLEPGTTVLD 408

  Fly   401 LAMKAKCFPTETDAVRIINAGGFYVNQKRVQNIAEVLTTGVHILRNGISLLRVGKRNFYIVRW 463
            ...:|:..|......::|..||.::|.:|.:|..:||..|..||.||:||:||||:||:|::|
Zfish   409 ACRRARAIPDGPRGYQMIKDGGVWINHQRAENPEQVLIVGQQILSNGLSLIRVGKKNFHILKW 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TyrRS-m	NP_611967.1	PRK05912	23..463	CDD:235645	219/443 (49%)
TyrRS-m	NP_611967.1	TyrRS_core	58..345	CDD:173902	163/289 (56%)
yars2	NP_001137392.1	PRK05912	43..471	CDD:235645	217/434 (50%)
yars2	NP_001137392.1	TyrRS_core	70..353	CDD:173902	163/289 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596900
Domainoid	1	1.000	348	1.000	Domainoid score	I1000
eggNOG	1	0.900	-	-		E1_COG0162
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7097
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1643
OMA	1	1.010	-	-		QHG62672
OrthoDB	1	1.010	-	-		D419291at33208
OrthoFinder	1	1.000	-	-		FOG0004408
OrthoInspector	1	1.000	-	-		oto39053
orthoMCL	1	0.900	-	-		OOG6_101423
Panther	1	1.100	-	-	LDO	PTHR11766
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1462
SonicParanoid	1	1.000	-	-		X3126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800