Protein Alignment TyrRS-m and YARS2

DIOPT Version :10

• Sequence 1: NP_611967.1
• Gene: TyrRS-m / 37965
• FlyBaseID: FBgn0035064
• Length: 464
• Species: Drosophila melanogaster
• Sequence 2: NP_001035526.1
• Gene: YARS2 / 51067
• HGNCID: 24249
• Length: 477
• Species: Homo sapiens
• Alignment Length: 465
• Identity: 220/465 - (47%)
• Similarity: 301/465 - (64%)
• Gaps: 13/465 - (2%)

  Fly     4 LRRSLLKPLQDVLRHSHRQMSQKNLLELTDRGFFHGIFPDTAAP-RMKQLFTRG----QQSIYAG 63
            |..|:|.||.  ||.:| ..:|..|.....||.|...||:|... .:.:||.||    .|:||.|
Human    18 LNLSVLLPLG--LRKAH-SGAQGLLAAQKARGLFKDFFPETGTKIELPELFDRGTASFPQTIYCG 79

  Fly    64 FDPTADSLHVGNLLVIMGLIHCQRAGHRPIALVGGATGLIGDPSGRKTERNQLGETVIETNLKAI 128
            |||||||||||:||.::||.|.|||||..||||||||..:||||||..||..|....:..|.:|:
Human    80 FDPTADSLHVGHLLALLGLFHLQRAGHNVIALVGGATARLGDPSGRTKEREALETERVRANARAL 144

  Fly   129 EQQLRRVFENHENCLWDSKKQKLPLAPLIIVNNADWYADLQLIDFVANMGRHFRMGSMLSRSSVQ 193
            ...|..:..||:....|.:.    .....:::|:.||....|:||:|.:|.|||||::|||.|||
Human   145 RLGLEALAANHQQLFTDGRS----WGSFTVLDNSAWYQKQHLVDFLAAVGGHFRMGTLLSRQSVQ 205

  Fly   194 SRLESEDGMSFTEFTYQIFQAYDWLHLLRRHNCCFQMGGSDQTGNLMTGHELISRVERKREVFGL 258
            .||:|.:|||..||.||:.||||:.:|.:|:.|..|:|||||.||:|:|:|.|:::..: :|||:
Human   206 LRLKSPEGMSLAEFFYQVLQAYDFYYLFQRYGCRVQLGGSDQLGNIMSGYEFINKLTGE-DVFGI 269

  Fly   259 TLPLVTTEEGDKFGKSAGNAVWLDGNKTSPFALYQFFLRMPDSEVEKLLKLFTFIPLPQVEQLMR 323
            |:||:|:..|.|.||||||||||:.:|||||.|||||:|.||..||:.||||||:|||:::.:|:
Human   270 TVPLITSTTGAKLGKSAGNAVWLNRDKTSPFELYQFFVRQPDDSVERYLKLFTFLPLPEIDHIMQ 334

  Fly   324 EHTKEPEKRKAQTLLAEDVTLLVHGESGLKQAERVTNALYKGNVEGLAELNLSEIQQTFQGATMV 388
            .|.||||:|..|..||.:||.||||..||..|:|.|.|||..:::.|..::..|:::.|:.|...
Human   335 LHVKEPERRGPQKRLAAEVTKLVHGREGLDSAKRCTQALYHSSIDALEVMSDQELKELFKEAPFS 399

  Fly   389 NLLTEPGMSILELAMKAKCFPTETDAVRIINAGGFYVNQKRVQNIAEVLTTGVHILRNGISLLRV 453
            ....:||.|:|:...||...|......|:|..||..:|.::|.|...||..|.|||:||:|||::
Human   400 EFFLDPGTSVLDTCRKANAIPDGPRGYRMITEGGVSINHQQVTNPESVLIVGQHILKNGLSLLKI 464

  Fly   454 GKRNFYIVRW 463
            |||||||::|
Human   465 GKRNFYIIKW 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRS-m	NP_611967.1	TyrS	28..464	CDD:439932	211/441 (48%)
YARS2	NP_001035526.1	TyrS	38..474	CDD:439932	210/440 (48%)
		'HIGH' region. /evidence=ECO:0000305	82..91		8/8 (100%)
		'KMSKS' region. /evidence=ECO:0000305	281..285		2/3 (67%)