DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TyrRS-m and YARS2

DIOPT Version :9

Sequence 1:	NP_611967.1	Gene:	TyrRS-m / 37965	FlyBaseID:	FBgn0035064	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_001035526.1	Gene:	YARS2 / 51067	HGNCID:	24249	Length:	477	Species:	Homo sapiens

Alignment Length:	465	Identity:	220/465 - (47%)
Similarity:	301/465 - (64%)	Gaps:	13/465 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRRSLLKPLQDVLRHSHRQMSQKNLLELTDRGFFHGIFPDTAAP-RMKQLFTRG----QQSIYAG 63
            |..|:|.||.  ||.:| ..:|..|.....||.|...||:|... .:.:||.||    .|:||.|
Human    18 LNLSVLLPLG--LRKAH-SGAQGLLAAQKARGLFKDFFPETGTKIELPELFDRGTASFPQTIYCG 79

  Fly    64 FDPTADSLHVGNLLVIMGLIHCQRAGHRPIALVGGATGLIGDPSGRKTERNQLGETVIETNLKAI 128
            |||||||||||:||.::||.|.|||||..||||||||..:||||||..||..|....:..|.:|:
Human    80 FDPTADSLHVGHLLALLGLFHLQRAGHNVIALVGGATARLGDPSGRTKEREALETERVRANARAL 144

  Fly   129 EQQLRRVFENHENCLWDSKKQKLPLAPLIIVNNADWYADLQLIDFVANMGRHFRMGSMLSRSSVQ 193
            ...|..:..||:....|.:.    .....:::|:.||....|:||:|.:|.|||||::|||.|||
Human   145 RLGLEALAANHQQLFTDGRS----WGSFTVLDNSAWYQKQHLVDFLAAVGGHFRMGTLLSRQSVQ 205

  Fly   194 SRLESEDGMSFTEFTYQIFQAYDWLHLLRRHNCCFQMGGSDQTGNLMTGHELISRVERKREVFGL 258
            .||:|.:|||..||.||:.||||:.:|.:|:.|..|:|||||.||:|:|:|.|:::..: :|||:
Human   206 LRLKSPEGMSLAEFFYQVLQAYDFYYLFQRYGCRVQLGGSDQLGNIMSGYEFINKLTGE-DVFGI 269

  Fly   259 TLPLVTTEEGDKFGKSAGNAVWLDGNKTSPFALYQFFLRMPDSEVEKLLKLFTFIPLPQVEQLMR 323
            |:||:|:..|.|.||||||||||:.:|||||.|||||:|.||..||:.||||||:|||:::.:|:
Human   270 TVPLITSTTGAKLGKSAGNAVWLNRDKTSPFELYQFFVRQPDDSVERYLKLFTFLPLPEIDHIMQ 334

  Fly   324 EHTKEPEKRKAQTLLAEDVTLLVHGESGLKQAERVTNALYKGNVEGLAELNLSEIQQTFQGATMV 388
            .|.||||:|..|..||.:||.||||..||..|:|.|.|||..:::.|..::..|:::.|:.|...
Human   335 LHVKEPERRGPQKRLAAEVTKLVHGREGLDSAKRCTQALYHSSIDALEVMSDQELKELFKEAPFS 399

  Fly   389 NLLTEPGMSILELAMKAKCFPTETDAVRIINAGGFYVNQKRVQNIAEVLTTGVHILRNGISLLRV 453
            ....:||.|:|:...||...|......|:|..||..:|.::|.|...||..|.|||:||:|||::
Human   400 EFFLDPGTSVLDTCRKANAIPDGPRGYRMITEGGVSINHQQVTNPESVLIVGQHILKNGLSLLKI 464

  Fly   454 GKRNFYIVRW 463
            |||||||::|
Human   465 GKRNFYIIKW 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TyrRS-m	NP_611967.1	PRK05912	23..463	CDD:235645	211/444 (48%)
TyrRS-m	NP_611967.1	TyrRS_core	58..345	CDD:173902	151/286 (53%)
YARS2	NP_001035526.1	TyrS	43..474	CDD:333245	209/435 (48%)
		'HIGH' region. /evidence=ECO:0000305	82..91		8/8 (100%)
		'KMSKS' region. /evidence=ECO:0000305	281..285		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160506
Domainoid	1	1.000	332	1.000	Domainoid score	I1141
eggNOG	1	0.900	-	-		E1_COG0162
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7097
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1768
Isobase	1	0.950	-	0	Normalized mean entropy	S1500
OMA	1	1.010	-	-		QHG62672
OrthoDB	1	1.010	-	-		D419291at33208
OrthoFinder	1	1.000	-	-		FOG0004408
OrthoInspector	1	1.000	-	-		oto91737
orthoMCL	1	0.900	-	-		OOG6_101423
Panther	1	1.100	-	-	LDO	PTHR11766
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1462
SonicParanoid	1	1.000	-	-		X3126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750