DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TyrRS-m and SPCC576.06c

DIOPT Version :9

Sequence 1:	NP_611967.1	Gene:	TyrRS-m / 37965	FlyBaseID:	FBgn0035064	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_588433.1	Gene:	SPCC576.06c / 2539529	PomBaseID:	SPCC576.06c	Length:	445	Species:	Schizosaccharomyces pombe

Alignment Length:	427	Identity:	149/427 - (34%)
Similarity:	226/427 - (52%)	Gaps:	40/427 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 SIYAGFDPTADSLHVGNLLVIMGLIHCQRAGHRPIALVGGATGLIGDPSGRKTERNQLGETVIET 123
            |:|.|.||||.|||||||:.:|.|:|....|.....::|.||..:||||||.|.|.|:.||....
pombe    31 SVYLGADPTAASLHVGNLVALMPLVHFFLNGFPVFTVIGDATAQLGDPSGRSTSRKQMAETTRTA 95

  Fly   124 NLKAIEQQLR----RVFENHENCLWDSKKQKLPLAPL------IIVNNADWYADLQLIDFVANMG 178
            |..:|..||:    .:....::|       ..|.:.:      .||.|:.||.:|:|:.|::::|
pombe    96 NSNSIHNQLKDLSSSILSYAQDC-------NYPFSQMPSSSQWSIVRNSSWYENLKLLKFLSSVG 153

  Fly   179 RHFRMGSMLSRSSVQSRLESEDGMSFTEFTYQIFQAYDWLHLLRRHNCCFQMGGSDQTGNLMTGH 243
            .|.|:..||:|.||.:||:|..|:||.|.|||:.||||:.:|...|:...|:|||||.||:..|.
pombe   154 PHVRVSQMLARDSVTTRLQSPSGLSFAELTYQLLQAYDYSYLYENHSVNLQIGGSDQWGNITAGT 218

  Fly   244 ELISRVERKREVFGLTLPLVTTEEGDKFGKSAGNAVWLDGNKTSPFALYQFFLRMPDSEVEKLLK 308
            :|:.|......|:.||.||:|:..|.|.|||||||:|||...|..::|||:|:..||....|.|.
pombe   219 DLVRRTHPNANVYALTTPLLTSSSGQKLGKSAGNAIWLDPKLTDSYSLYQYFISAPDDLACKCLD 283

  Fly   309 LFTFIPLPQVEQLMREHTKEPEKRKAQTLLAEDVTLLVHGESGLKQAERVTNALY---------- 363
            :.|.:||.|:||:..||.|:|.:|.....||.:|..:|||:..|:.|:..|..|:
pombe   284 MLTLLPLEQLEQIKAEHEKDPSQRIVHKYLASNVVRMVHGKKALELAQIQTKLLHGAHQAPFGFY 348

  Fly   364 -KGNVEGLAELNLSEIQQTFQGA----TMVNLLTEPGMSILELAMKAKCFPTETDAVRIINAGGF 423
             :...:|.:..:|.||:..|:..    |:.:.:.:...|  .|....:.:.:..:|...|.:|..
pombe   349 SEAPQQGDSFPSLPEIRALFKDCKFYRTIDSSIKDQPFS--RLLRTLQIYTSRKEATEHILSGAV 411

  Fly   424 YVNQKRVQNIAEVLTTGVHILRNGISLLRVGKRNFYI 460
            .:..|      .:|.:......|.:.:||.|||.|.:
pombe   412 SLGHK------PILDSNYKFPDNSLFVLRAGKRTFVL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TyrRS-m	NP_611967.1	PRK05912	23..463	CDD:235645	149/427 (35%)
TyrRS-m	NP_611967.1	TyrRS_core	58..345	CDD:173902	122/295 (41%)
SPCC576.06c	NP_588433.1	TyrS	7..445	CDD:223240	149/427 (35%)
		TyrRS_core	31..320	CDD:173902	122/295 (41%)
		S4	389..443	CDD:214638	13/60 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	252	1.000	Domainoid score	I398
eggNOG	1	0.900	-	-		E1_COG0162
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7097
Inparanoid	1	1.050	257	1.000	Inparanoid score	I760
OMA	1	1.010	-	-		QHG62672
OrthoFinder	1	1.000	-	-		FOG0004408
OrthoInspector	1	1.000	-	-		oto102118
orthoMCL	1	0.900	-	-		OOG6_101423
Panther	1	1.100	-	-	LDO	PTHR11766
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1462
SonicParanoid	1	1.000	-	-		X3126
TreeFam	1	0.960	-	-
	13	12.950