DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3594 and RBM19

DIOPT Version :9

Sequence 1:	NP_523855.1	Gene:	CG3594 / 37964	FlyBaseID:	FBgn0035063	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_001140170.1	Gene:	RBM19 / 9904	HGNCID:	29098	Length:	960	Species:	Homo sapiens

Alignment Length:	199	Identity:	60/199 - (30%)
Similarity:	89/199 - (44%)	Gaps:	37/199 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 RNPSDPE---DSKSEDEAKSDDEAAAEGSAASGAEEEESAENGQITSDQLSSLLRGASKTNRHVL 116
            ::|::||   |.::.::....:|.|...||....||||..|.        ...|.|.:      |
Human   682 KDPAEPETVPDGETPEDENPTEEGADNSSAKMEEEEEEEEEE--------EESLPGCT------L 732

  Fly   117 YVTNLNFETTKDDLELHFSAAGTVKSIRIPKKRRG-------GFAFVEMADLSSFQNAF-QLHNT 173
            ::.||||:||::.|:..||..|||||..|.||:..       ||.|||.......|.|. ||...
Human   733 FIKNLNFDTTEEKLKEVFSKVGTVKSCSISKKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGH 797

  Fly   174 ELQGRNIKVQISEAGKKKS---ANKKNI-IKQKNRKL--------AEMRNEQKTFTKSGKFYDKD 226
            .:.|..::|:|||...|.:   |.||.: .||...|:        |..|..::.|:..|:.....
Human   798 VVDGHKLEVRISERATKPAVTLARKKQVPRKQTTSKILVRNIPFQAHSREIRELFSTFGELKTVR 862

  Fly   227 LKKE 230
            |.|:
Human   863 LPKK 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3594	NP_523855.1	RRM3_Prp24	114..184	CDD:240744	29/77 (38%)
RBM19	NP_001140170.1	RRM	<2..>104	CDD:223796
		RRM1_RBM19	2..77	CDD:241008
		RRM_u2	82..286	CDD:293257
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..119
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..294
		RRM	<270..450	CDD:223796
		RRM2_RMB19	294..365	CDD:240946
		RRM	<400..>500	CDD:223796
		RRM3_RBM19	400..478	CDD:241011
		RRM	477..801	CDD:223796	42/132 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..513
		RRM4_RBM19	587..658	CDD:241013
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..729		14/54 (26%)
		RRM5_RBM19_like	730..809	CDD:240764	29/84 (35%)
		RRM6_RBM19	832..910	CDD:241015	7/35 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0110
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810