DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3594 and RBM34

DIOPT Version :9

Sequence 1:	NP_523855.1	Gene:	CG3594 / 37964	FlyBaseID:	FBgn0035063	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_055829.2	Gene:	RBM34 / 23029	HGNCID:	28965	Length:	430	Species:	Homo sapiens

Alignment Length:	189	Identity:	53/189 - (28%)
Similarity:	93/189 - (49%)	Gaps:	28/189 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 DDEAAAEGSAASGAEEEESAENGQITSDQLSSLLRGASKTNRHVLYVTNLNFETTKDDLELHFSA 136
            ::.||.:....:||   :.|:..:|..|..|.    .|..::..::|.||.::..:..:|.||..
Human   252 EESAATQALKRNGA---QIADGFRIRVDLASE----TSSRDKRSVFVGNLPYKVEESAIEKHFLD 309

  Fly   137 AGTVKSIRIPK-KRRG---GFAFVEMADLSSFQNAFQLHNTELQGRNIKVQISEAGKKKSANKKN 197
            .|::.::||.: |..|   ||.:|...:..|...|.:|:|:||.||.::|.       :|.||:.
Human   310 CGSIMAVRIVRDKMTGIGKGFGYVLFENTDSVHLALKLNNSELMGRKLRVM-------RSVNKEK 367

  Fly   198 IIKQKNRKLAEMRNEQK-----TFT-KSGKFYDKDL-KKEKAKEMLARKRWRKKPAPRP 249
             .||:|.. ..::|..|     .|| |:.:.:.|.| ..|||..:..:|:.:|| :.||
Human   368 -FKQQNSN-PRLKNVSKPKQGLNFTSKTAEGHPKSLFIGEKAVLLKTKKKGQKK-SGRP 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3594	NP_523855.1	RRM3_Prp24	114..184	CDD:240744	23/73 (32%)
RBM34	NP_055829.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..123
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..153
		RRM	176..>382	CDD:223796	39/145 (27%)
		RRM1_RBM34	185..276	CDD:240840	6/26 (23%)
		RRM2_RBM34	288..360	CDD:240841	22/71 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..395		9/31 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..430		5/14 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2864
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23236
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960