back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment egg and SETDB1

DIOPT Version :9

Sequence 1:	NP_611966.3	Gene:	egg / 37962	FlyBaseID:	FBgn0086908	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	NP_001353346.1	Gene:	SETDB1 / 9869	HGNCID:	10761	Length:	1292	Species:	Homo sapiens

Alignment Length:	1381	Identity:	402/1381 - (29%)
Similarity:	577/1381 - (41%)	Gaps:	448/1381 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 VELEKGTAPKAAED---------EKLNALLSDGDVFYDKECVNCNCTKLHKQYVLANMATLNFYQ 289
            :.|:..||...:|:         |:|...:.:...|.|:|....:|.:..|:. ||.:.|    .
Human     8 IGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ-LAELET----W 67

  Fly   290 VLRKSSKQQFLCMGCHDTAMDLYEEYAGQLMAKQPLLLKDFHQDHADFVAL---DSSDEEEEEKQ 351
            |::|.|:.      .|   :|...:.|.:.:.....|:|||:..    :.|   |||.|:|..:.
Human    68 VIQKESEV------AH---VDQLFDDASRAVTNCESLVKDFYSK----LGLQYRDSSSEDESSRP 119

  Fly   352 PEKSDFSKNKLQLIEDELDDAIKNVLNKVDFTAQLSWSKTILQAKADHLERQFALADVELEKVQT 416
            .|..:        |.||.||.:.  ::..|..::....:.:.:|.|            .|.|...
Human   120 TEIIE--------IPDEDDDVLS--IDSGDAGSRTPKDQKLREAMA------------ALRKSAQ 162

  Fly   417 TADKMHCALYNSCPVAHKHLPTLDIEPSDYVHEVPPPGEIVRPPIQLGETYYAVKNKAIASWVSI 481
            ...|...|:.........|..||    |....|:...|:::.....||:       |...:|
Human   163 DVQKFMDAVNKKSSSQDLHKGTL----SQMSGELSKDGDLIVSMRILGK-------KRTKTW--- 213

  Fly   482 KVIEFTESTAINGNTM---KSYKIRYLNTPYQMIKTVTAKHIAY-FEPPPVRLTIGTRVIA-YFD 541
                 .:.|.|...|:   |.||:::.|....::   :..|||| :.||..:|.:|:||:| |.|
Human   214 -----HKGTLIAIQTVGPGKKYKVKFDNKGKSLL---SGNHIAYDYHPPADKLYVGSRVVAKYKD 270

  Fly   542 GTTLSRGKDKGVVQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYVPHRDVRLVCQASEKVWEDV 606
            |.           |...|.||:||.....|:.|:|||:||||..||...::..:|:..:|.|||:
Human   271 GN-----------QVWLYAGIVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDI 324

  Fly   607 HAAS-RDFIQKYVEKYSVDRPMVQCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTEW 670
            ...| ||||::||..|. :||||....||.:.||..|||..:||.::|.|||.:.|..|| ..||
Human   325 EDISCRDFIEEYVTAYP-NRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDK-RCEW 387

  Fly   671 IYRGSLRLGPVFRETQNNMNSSSAQ-------QLR------VPRRTEPFIRYTKEMESS------ 716
            |||||.||.|:|     :|.:|||.       |||      ..|...|.::||:::..:
Human   388 IYRGSTRLEPMF-----SMKTSSASALEKKQGQLRTRPNMGAVRSKGPVVQYTQDLTGTGTQFKP 447

  Fly   717 -------------------------------SKVNQQMRAFARKSSASAQNNALAAASSAATPA- 749
                                           |::.|..:..|:||::....:..:..||..:||
Human   448 VEPPQPTAPPAPPFPPAPPLSPQAGDSESLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTSPAL 512

  Fly   750 -----GG--------RTNAGGVSTSNSASAVRHLNNSTIYVDDENRPKGHVVYFTAKRNLPPKMY 801
                 ||        |:..|..:::.:.||:.......::.....|......|......|   .|
Human   513 SENVSGGKPGINQTYRSPLGSTASAPAPSALPAPPAPPVFHGMLERAPAEPSYRAPMEKL---FY 574

  Fly   802 KCHECSPNCLFKI-VHRLDSY---SPLAKPLLSGWERLVMRQKTKKS----VVYKGPCGKSLRSL 858
            ..|.||..||.:: ..|.:.|   :||..|||..:.|:..|::..:.    |:||.|||..||::
Human   575 LPHVCSYTCLSRVRPMRNEQYRGKNPLLVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTM 639

  Fly   859 AEVHRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVKD------------TDISKGQEKMAIP 911
            .|:.|||           |:...|...|..:.:||.::.|            .||:.|:|.:.:.
Human   640 QEIERYL-----------FETGCDFLFLEMFCLDPYVLVDRKFQPYKPFYYILDITYGKEDVPLS 693

  Fly   912 LVNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSKCACWQLTVAGVRYCNPK 976
            .||..|.|.||...|:|:|||.:||.:|...|||:.|||:|.|.|||||||.|||:.... |.|.
Human   694 CVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTIQATA-CTPG 757

  Fly   977 KPIE-EIGYQYKRLHEHVPTGIYECNSRCKCKKN-CLNRVVQFSLEMKLQVFKTSNRGWGLRCVN 1039
            ..|. ..|||||||.|.:|||:||||.||||..| |.||:||..|:::||:|||.|:|||:||::
Human   758 GQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLD 822

  Fly  1040 DIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKEGYESEV------------ 1092
            ||.||:|:|||||.:||:..|::.|.:.||||||:||:||..|..||||||:.
Human   823 DIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLK 887

  Fly  1093 ------------DHSDPDAEEDN------------------------------------------ 1103
                        :.|:.|:.:||
Human   888 DQEDGNSGTEDPEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPD 952

  Fly  1104 --------------GG---PDA------------------------------------------- 1108
                          ||   |.:
Human   953 LGPPHIPVPPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGG 1017

  Fly  1109 --------------------------EDDDD---------------FRP---------------N 1117
                                      ||.||               :.|               :
Human  1018 SRMEAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKTS 1082

  Fly  1118 YHYQRKIKRSSRSGS----TQNSSTQS-----------------SELDSQERAVINFNPNAD--- 1158
            .|..|::..|::|..    |.:|||:|                 :.:||.:...|:.....|
Human  1083 MHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGSEGDDFE 1147

  Fly  1159 ----------------------LDET--------------------VRENSVRRLFGKDEAPYIM 1181
                                  |..|                    ||:|: |:.:..:|:.||:
Human  1148 DKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNT-RQFYDGEESCYII 1211

  Fly  1182 DAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGK 1246
            |||..||||||.||||||||||||||||||||||||||||::..||:||||||:||||||.|.||
Human  1212 DAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTELTWDYNYEVGSVEGK 1276

  Fly  1247 VLYCQCGAPNCRLRLL 1262
            .|.|.|||..||.|||
Human  1277 ELLCCCGAIECRGRLL 1292

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.