DRSC/TRiP Functional Genomics Resources

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Protein Alignment egg and KMT2B

DIOPT Version :9

Sequence 1:NP_611966.3 Gene:egg / 37962 FlyBaseID:FBgn0086908 Length:1262 Species:Drosophila melanogaster
Sequence 2:NP_055542.1 Gene:KMT2B / 9757 HGNCID:15840 Length:2715 Species:Homo sapiens


Alignment Length:125 Identity:39/125 - (31%)
Similarity:53/125 - (42%) Gaps:29/125 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  1156 NADLDETVRENS---VRRLF---------GKDEAPY--------IMDAKTTGNLGRYFNHSCSPN 1200
            |.|..|.|.|.|   :|.:.         ||....|        ::||...||..|:.||||.||
Human  2594 NIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPN 2658

  Fly  1201 LFVQNVFVD--THDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCR 1258
            .|.:.:.|:  .|      :..|:...|..|.|||::|.:.:.....| |.|.|||..||
Human  2659 CFSRVIHVEGQKH------IVIFALRRILRGEELTYDYKFPIEDASNK-LPCNCGAKRCR 2711

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
eggNP_611966.3 HMT_MBD 823..879 CDD:238689
Pre-SET 901..1013 CDD:282838
SET 1022..1239 CDD:214614 31/104 (30%)
KMT2BNP_055542.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..65
Menin-binding motif (MBM). /evidence=ECO:0000269|PubMed:22327296 17..36
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..302
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 320..518
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..771
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 819..868
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 894..959
zf-CXXC 958..1005 CDD:251032
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1027..1132
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1146..1166
PHD1_KMT2B 1203..1249 CDD:277064
PHD2_KMT2B 1251..1300 CDD:277066
PHD3_KMT2B 1337..1393 CDD:277068
Bromo_ALL-1 1374..1516 CDD:99925
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1545..1567
ePHD_KMT2B 1581..1685 CDD:277164
FYRN 1734..1780 CDD:283589
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1806..1978
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2008..2093
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2118..2162
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2280..2412
FYRC 2413..2497 CDD:197781
WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483 2508..2513
SET <2559..2715 CDD:225491 39/125 (31%)
SET 2577..2697 CDD:214614 31/108 (29%)