DRSC/TRiP Functional Genomics Resources

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Protein Alignment egg and Setdb1

DIOPT Version :9

Sequence 1:NP_611966.3 Gene:egg / 37962 FlyBaseID:FBgn0086908 Length:1262 Species:Drosophila melanogaster
Sequence 2:NP_001157113.1 Gene:Setdb1 / 84505 MGIID:1934229 Length:1308 Species:Mus musculus


Alignment Length:1399 Identity:405/1399 - (28%)
Similarity:573/1399 - (40%) Gaps:480/1399 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   241 APKAAED-----------EKLNALLSDGDVFYDKECVNCNCTKLHKQYVLANMATLNFYQVLRKS 294
            ||.||:.           |:|...:.:...:.|:|....:|.:..|:. ||.:.|    .||:|.
Mouse    13 APAAADSAEIAELQQAVVEELGISMEELRQYIDEELEKMDCIQQRKKQ-LAELET----WVLQKE 72

  Fly   295 SKQQFLCMGCHDTAMDLYEEYAGQLMAKQPLLLKDFH-----QDHADFVALDSSDEEEEEKQPEK 354
            |:..:         :|...:.|.:.:.....|:|||:     |.|      |||.|:|..:..|.
Mouse    73 SEVAY---------VDRLFDDASREVTNCESLVKDFYSKLGLQYH------DSSSEDEASRPTEI 122

  Fly   355 SDFSKNKLQLIEDELDDAIKNVLNKVDFTAQLSWSKTILQAKADHLERQFALADVELEKVQTTAD 419
            .:        |.||.||.:.  ::..|..::....:.:.:|.|            .|.|......
Mouse   123 IE--------IPDEDDDVLS--IDSGDAGSRTPKDQKLREAMA------------ALRKSAQDVQ 165

  Fly   420 KMHCALYNSCPVAHKHLPTLDIEPSDYVHEVPPPGEIVRPPIQLGETYYAVKNKAIASWVSIKVI 484
            |...|:.........|..||    .....|:...|:::.....||:       |...:|      
Mouse   166 KFMDAVNKKSSSQDLHKGTL----GQVSGELSKDGDLIVSMRILGK-------KRTKTW------ 213

  Fly   485 EFTESTAINGNTM---KSYKIRYLNTPYQMIKTVTAKHIAY-FEPPPVRLTIGTRVIA-YFDGTT 544
              .:.|.|...|:   |.||:::.|....::   :..|||| :.||..:|.:|:||:| |.||. 
Mouse   214 --HKGTLIAIQTVGLGKKYKVKFDNKGKSLL---SGNHIAYDYHPPADKLFVGSRVVAKYKDGN- 272

  Fly   545 LSRGKDKGVVQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYVPHRDVRLVCQASEKVWEDVHAA 609
                      |...|.||:||.....|:.|:|||:||||..||...::..:|:..:|.|||:..:
Mouse   273 ----------QVWLYAGIVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDS 327

  Fly   610 S-RDFIQKYVEKYSVDRPMVQCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTEWIYR 673
            | ||||::|:..|. :||||....||.:.||..|||..:||.::|.|||.:.|..|| ..|||||
Mouse   328 SCRDFIEEYITAYP-NRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDK-RCEWIYR 390

  Fly   674 GSLRLGPVFRETQNNMNSSSAQ--------QLR------VPRRTEPFIRYTKEM----------- 713
            ||.||.|:|     :|.:|||.        |||      ..|...|.::||:::           
Mouse   391 GSTRLEPMF-----SMKTSSASAMEKKQGGQLRTRPNMGAVRSKGPVVQYTQDLTGTGIQFKPME 450

  Fly   714 -----------------------ESSSKVNQQMRAFARKSSASAQNNALAAASSAATPA--GGRT 753
                                   ||......|.|....|.|.|.:..::.:..|:.|.:  ....
Mouse   451 PLQPIAPPAPLPIPPLSPQAADTESLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTSSTLSENV 515

  Fly   754 NAG--GVS----------TSNSASA---VRHLNNSTIYVDDENRPKGHVVYFTAKRNLPPK---- 799
            :||  |::          ||..|||   |..:............|.|.:.        ||.    
Mouse   516 SAGKLGINQTYRSPLASVTSTPASAAPPVPPVPPGPPTPPGPPAPPGPLA--------PPAFHGM 572

  Fly   800 -----------------MYKCHECSPNCLFKI-VHRLDSY---SPLAKPLLSGWERLVMRQKTKK 843
                             .|..|.||..||.:| ..|.:.|   :||..|||..:.|:..|::..:
Mouse   573 LERAPAEPSYRAPMEKLFYLPHVCSYTCLSRIRPMRNEQYRGKNPLLVPLLYDFRRMTARRRVNR 637

  Fly   844 S----VVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVKD------ 898
            .    |:||.|||..||::.|:.|||           |:...|...|..:.:||.::.|      
Mouse   638 KMGFHVIYKTPCGLCLRTMQEIERYL-----------FETGCDFLFLEMFCLDPYVLVDRKFQPF 691

  Fly   899 ------TDISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDK 957
                  .||:.|:|.:.:..||..|.|.||...|:|:|||.:||.:|...|||:.|||:|.|.||
Mouse   692 KPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDK 756

  Fly   958 SKCACWQLTVAGVRYCNPKKPIE-EIGYQYKRLHEHVPTGIYECNSRCKCKKN-CLNRVVQFSLE 1020
            |||||.|||:.... |.|...:. ..|||||||.|.:|||:||||.||.|..| |.||:||..|:
Mouse   757 SKCACHQLTIQATA-CTPGGQVNPNSGYQYKRLEECLPTGVYECNKRCNCDPNMCTNRLVQHGLQ 820

  Fly  1021 MKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLK 1085
            ::||:|||.|:|||:||::||.||:|:|||||.:||:..|::.|.:.||||||:||:||..|..|
Mouse   821 VRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIESVENFK 885

  Fly  1086 EGYESEV------------------------DHSDPDAEEDN----------------------- 1103
            |||||:|                        :.|:.|:.:||                       
Mouse   886 EGYESDVPTSSDSSGVDMKDQEDGNSGSEDPEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTR 950

  Fly  1104 ---------------------------------GG---PDAED---------------------D 1111
                                             ||   |.:|:                     |
Mouse   951 GQKENELSEMTSKDSRPPDLGPPHVPIPSSVSVGGCNPPSSEETPKNKVASWLSCNSVSEGGFAD 1015

  Fly  1112 DDFRPNYHYQR-----------KIKRSSRSG---------------------------------- 1131
            .|.|.::....           :.:|:|.||                                  
Mouse  1016 SDSRSSFKTSEGGDGRAGGGRGEAERASTSGLSFKDEGDNKQPKKEDPENRNKMPVVTEGSQNHG 1080

  Fly  1132 ---------------------------STQ---------NSSTQS-----------------SEL 1143
                                       |||         :|||:|                 :.:
Mouse  1081 HNPPMKSEGLRRSASKMSVLQSQRVVTSTQSNPDDILTLSSSTESEGESGTSRKPTAGHTSATAV 1145

  Fly  1144 DSQERAVINFNPNAD-------------------------LDET--------------------V 1163
            ||.:...|:...:.|                         |..|                    |
Mouse  1146 DSDDIQTISSGSDGDDFEDKKNLSGPTKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPV 1210

  Fly  1164 RENSVRRLFGKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRS 1228
            |:|: |:.:..:|:.||:|||..||||||.||||||||||||||||||||||||||||::..||:
Mouse  1211 RKNT-RQFYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRA 1274

  Fly  1229 GTELTWNYNYEVGVVPGKVLYCQCGAPNCRLRLL 1262
            ||||||:||||||.|.||.|.|.|||..||.|||
Mouse  1275 GTELTWDYNYEVGSVEGKELLCCCGAIECRGRLL 1308

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
eggNP_611966.3 HMT_MBD 823..879 CDD:238689 20/59 (34%)
Pre-SET 901..1013 CDD:282838 57/113 (50%)
SET 1022..1239 CDD:214614 125/463 (27%)
Setdb1NP_001157113.1 YlqD <24..98 CDD:287979 16/87 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 127..148 5/22 (23%)
TUDOR 257..317 CDD:197660 26/70 (37%)
TUDOR 348..400 CDD:197660 27/57 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 404..424 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..571 10/46 (22%)
MBD 615..690 CDD:128673 25/85 (29%)
PreSET 697..804 CDD:128744 54/107 (50%)
SET 821..>884 CDD:214614 36/62 (58%)
S-adenosyl-L-methionine binding. /evidence=ECO:0000250 831..833 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 886..1175 32/288 (11%)
SET <1223..1285 CDD:214614 49/61 (80%)