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Protein Alignment egg and SETDB2

DIOPT Version :9

Sequence 1:	NP_611966.3	Gene:	egg / 37962	FlyBaseID:	FBgn0086908	Length:	1262	Species:	Drosophila melanogaster
Sequence 2:	NP_114121.2	Gene:	SETDB2 / 83852	HGNCID:	20263	Length:	719	Species:	Homo sapiens

Alignment Length:	737	Identity:	218/737 - (29%)
Similarity:	318/737 - (43%)	Gaps:	156/737 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   663 GDKN---HTEWI-YRGSLRLGPVFRETQNNMNSSSAQQLRVPRRTEPFIRYTKE-MESSSKVNQQ 722
            |:||   .|.|: .....::..:|.:.||.:.|.. |:::....|      .|| :::...||:.
Human     2 GEKNGDAKTFWMELEDDGKVDFIFEQVQNVLQSLK-QKIKDGSAT------NKEYIQAMILVNEA 59

  Fly   723 MRAFARKSSASAQNNALAAASSAATPAGGRTNAGGVSTSNSASAVRHLNNSTIYVDDENRP---- 783
            ....:..|...|....:.|.||...|...:......:...|.|..........::..||:.
Human    60 TIINSSTSIKGASQKEVNAQSSDPMPVTQKEQENKSNAFPSTSCENSFPEDCTFLTTENKEILSL 124

  Fly   784 KGHVVYFTAKRNLPPKMYKCHECSPNCLFKIVHRLDSYSPLAKPLLSGWERLVMRQKTKKS---V 845
            :..||.|..|.:.....|:.|:||..||.|:...|...:||..|:...::|...:..:..|   |
Human   125 EDKVVDFREKDSSSNLSYQSHDCSGACLMKMPLNLKGENPLQLPIKCHFQRRHAKTNSHSSALHV 189

  Fly   846 VYKGPCGKSLRSLAEVHRYLRATE-NVLNVDNFDFTPDLKCLAEYSIDPSIVKDTDISKGQEKMA 909
            .||.|||:|||::.||.|||..|| |.|..|||.|...::....|.....:|.|.|||.|.|.:.
Human   190 SYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYVQLARNYPKQKEVVSDVDISNGVESVP 254

  Fly   910 IPLVNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSKCACWQLTVAGVRYCN 974
            |...|..|:...|...|.|...|......|....|...|||.:.|.|.:||||.|||....:
Human   255 ISFCNEIDSRKLPQFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCIDITKCACLQLTARNAK--- 316

  Fly   975 PKKPIEE----IGYQYKRLHEHVPTGIYECNSRCKCKKN-CLNRVVQFSLEMKLQVFKTSNRGWG 1034
             ..|:..    .||:||||...:|||||||:..|||.:. |.|||||...:::||||||..:|||
Human   317 -TSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWG 380

  Fly  1035 LRCVNDIPKGAFICIYAGHLLTETMA------NEGGQDAG--DEYFADLDYIEVA------EQLK 1085
            :||::||.:|.|:|||:|.||:....      :|.|:|..  ...|:....:|||      |.|.
Human   381 VRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDENGRDENTMKNIFSKKRKLEVACSDCEVEVLP 445

  Fly  1086 EGYE-------------------------------SEVD-HS---DPDAE----EDNG------- 1104
            .|.|                               |.:. ||   ||:::    :.||
Human   446 LGLETHPRTAKTEKCPPKFSNNPKELTVETKYDNISRIQYHSVIRDPESKTAIFQHNGKKMEFVS 510

  Fly  1105 --GPDAEDDDDFR-PNYHYQRKIKRSSRSGST----------------------------QNSST 1138
              ....||:|.|: |..|...|.|.:.:..|:                            ::...
Human   511 SESVTPEDNDGFKPPREHLNSKTKGAQKDSSSNHVDEFEDNLLIESDVIDITKYREETPPRSRCN 575

  Fly  1139 QSSELDSQ----------------------------ERAVINFNPNADLDETVRENSVRRLFGKD 1175
            |::.||:|                            :..:::...|...|...:       |.|.
Human   576 QATTLDNQNIKKAIEVQIQKPQEGRSTACQRQQVFCDEELLSETKNTSSDSLTK-------FNKG 633

  Fly  1176 EAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEV 1240
            .. :::||...||:||:.||||.|||.||||||:||:..||.||||:..::::.|||||:|.||.
Human   634 NV-FLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEA 697

  Fly  1241 GVVPGKVLYCQCGAPNCRLRLL 1262
            |.||.|.::||||...||.::|
Human   698 GTVPEKEIFCQCGVNKCRKKIL 719

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.