Protein Alignment egg and EHMT1

DIOPT Version :10

• Sequence 1: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: XP_011517323.1
• Gene: EHMT1 / 79813
• HGNCID: 24650
• Length: 1301
• Species: Homo sapiens
• Alignment Length: 1444
• Identity: 288/1444 - (19%)
• Similarity: 458/1444 - (31%)
• Gaps: 577/1444 - (39%)

  Fly     5 PTAVDCLESSGSTVEDVQETPASREKSYGLPVRKGENSLESPAEQAAKDVE-------------- 55
            |.:|..|.::.....:|:|....:|                |.|:..|::.
Human   211 PKSVVGLHAASKDPREVREARDHKE----------------PKEEINKNISDFGRQQLLPPFPSL 259

  Fly    56 IEELTHSEAIAATGSTRKQC-PYGGKAPDEPGKLADESEDRKG-------ENTKAIASSPVLVAV 112
            .:.|..::...||..::..| |:...|     .::.:.:.|.|       :.||.:....|
Human   260 HQSLPQNQCYMATTKSQTACLPFVLAA-----AVSRKKKRRMGTYSLVPKKKTKVLKQRTV---- 315

  Fly   113 DSDSSVELIESPVKFSSANESEKD-----------PPKPDAVNEAAAKEAEEMTDSSISSPTSES 166
                 :|:.:|....:..::.|||           ..:.|: :|..::|.||  |....:..:.:
Human   316 -----IEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDS-DEDDSEELEE--DDGHGAEQAAA 372

  Fly   167 FPEKDEKTNKEN------------------------EQEPPGMEVDQDVEESIS----------- 196
            ||.:|.:|:||:                        |:|..|.|.|...|.||.
Human   373 FPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIKKKFLKRKGKTD 437

  Fly   197 ----RPA-----------------EEYK-----IENTL----KGHKRISLTEIEEHKIVDKKDDV 231
                :||                 |.||     .|.|.    .|:..:||             |.
Human   438 SPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVSL-------------DS 489

  Fly   232 LEVELEKGTAPKAAEDEKLNALLSDGDVFYD---KECVNCNC----TKLHKQYVLAN---MATLN 286
            |::.: ||.....||     .|.:..||...   :|...|:|    .|..:...|||   |||.:
Human   490 LDLRV-KGILSSQAE-----GLANGPDVLETDGLQEVPLCSCRMETPKSREITTLANNQCMATES 548

  Fly   287 F-------------YQVLRKSSKQQFL---------------CMGCHDTAMDLYEEYAGQLMAKQ 323
            .             |:::|.|:|...|               |.||.      |...||..|..|
Human   549 VDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCG------YFCTAGNFMECQ 607

  Fly   324 P--LLLKDFHQDHADFVALDSSDEEEEEKQPEKSDFSKNKLQLIEDELDDAIKNVLNKVDFT--- 383
            |  .:...||:|.|..|                                       |...:.
Human   608 PESSISHRFHKDCASRV---------------------------------------NNASYCPHC 633

  Fly   384 -AQLSWSKTILQAKADHLERQFALADVELEKVQTTADKMHCALYNSCPVAHKHLPTLDIEPSDYV 447
             .:.|.:|.:..||||                 ||:.
Human   634 GEESSKAKEVTIAKAD-----------------TTST---------------------------- 653

  Fly   448 HEVPPPGEIVRPPIQLGETYYAVKNKAIASWVSIKVIEFTESTAINGNTMKSYKIRYLNTPYQMI 512
             ..|.||:         |...|::.:|..:..|......:|...:.|
Human   654 -VTPVPGQ---------EKGSALEGRADTTTGSAAGPPLSEDDKLQG------------------ 690

  Fly   513 KTVTAKHIAY-FEPP-PV---RLTIGTRVIAYFDGTTLSRGKDKGVVQSA-------------FY 559
               .|.|:.. |:|. |.   |.|.|           ||:|..|..::||             |:
Human   691 ---AASHVPEGFDPTGPAGLGRPTPG-----------LSQGPGKETLESALIALDSEKPKKLRFH 741

  Fly   560 PGIIAEPLKQANRYRYLIFYDDGYTQ--YVPHRDVRLVCQASEKVWEDVHAASRDFIQKYVEKYS 622
            |..:....:|....:.|:...||...  .:.|::.|          ..:|||:        |...
Human   742 PKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKR----------SPLHAAA--------EAGH 788

  Fly   623 VDRPMVQCTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNHTE---WIYRGSLRLGPVFRE 684
            ||...:....|.::.|.|.           |....||: ..:.||.|   ::.:....:.|
Human   789 VDICHMLVQAGANIDTCSE-----------DQRTPLME-AAENNHLEAVKYLIKAGALVDP---- 837

  Fly   685 TQNNMNSSSAQQLRVPRRTEPFIRYTKEMESSSKVNQQMRAFARKSSASAQNNALAAASSAATPA 749
              .:...|:...|...:.....::|...       |.||       ..:.|::
Human   838 --KDAEGSTCLHLAAKKGHYEVVQYLLS-------NGQM-------DVNCQDD------------ 874

  Fly   750 GGRTNAGGVSTSNSASAVRHLN--------NSTIYV-DDENRPKGHVVYFTAKRNLPPKMY--KC 803
                  ||.:....|:..:|::        .|.|.: |:|.....|...|:...::...:.  ||
Human   875 ------GGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKC 933

  Fly   804 -------HECSPNCLFKIVHRLDSYSPLAKPLLSGWERLVMRQKTKKSVVYKGPCGKSLRSLAEV 861
                   |..||   ..|..|.:.|..:.. .||....:.::.|..::.:........:.|..::
Human   934 DLHAVNIHGDSP---LHIAARENRYDCVVL-FLSRDSDVTLKNKEGETPLQCASLNSQVWSALQM 994

  Fly   862 HRYLRATENVLNVDNFDFTPDLKCLAEYSIDPSIVK---DTDISKGQEKMAIPLVNYYDNTLPPP 923
            .:.|:           |..||         .||.|:   ..||::|.|::.||.||..|:   .|
Human   995 SKALQ-----------DSAPD---------RPSPVERIVSRDIARGYERIPIPCVNAVDS---EP 1036

  Fly   924 C----TYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSKCACWQLTVAGVRYCNPKKPIEEIGY 984
            |    .|..|...|..::::.:...|..|.|.|||| .|.|.|.||::.    |...|.    |.
Human  1037 CPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCS-SSNCMCGQLSMR----CWYDKD----GR 1092

  Fly   985 QYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICI 1049
            .....:...|..|:|||..|.|.:||.|||||..|..:||:::|.:.|||:|.:.|||.|.|:|.
Human  1093 LLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCE 1157

  Fly  1050 YAGHLLTETMANEGGQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDAEDDDDF 1114
            |.|.|::::.|:...:|:   |..|||
Human  1158 YVGELISDSEADVREEDS---YLFDLD-------------------------------------- 1181

  Fly  1115 RPNYHYQRKIKRSSRSGSTQNSSTQSSELDSQERAVINFNPNADLDETVRENSVRRLFGKDEAPY 1179
                                                                      .||...|
Human  1182 ----------------------------------------------------------NKDGEVY 1188

  Fly  1180 IMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVP 1244
            .:||:..||:.|:.||.|.|||....||:...|||||.:||||...|.:|.:|.::|......:.
Human  1189 CIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIK 1253

  Fly  1245 GKVLYCQCGAPNCR 1258
            ||:..|:||:|.||
Human  1254 GKLFSCRCGSPKCR 1267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	Tudor_SETDB1_rpt1	532..622	CDD:410453	19/104 (18%)
		Tudor_SETDB1_rpt2	630..684	CDD:410548	10/56 (18%)
		HMT_MBD	823..879	CDD:238689	5/55 (9%)
		SET_SETDB1	900..1262	CDD:380915	103/363 (28%)
EHMT1	XP_011517323.1	EHMT_ZBD	517..647	CDD:411018	32/174 (18%)
		ANKYR	723..979	CDD:440430	54/327 (17%)
		ANK repeat	745..771	CDD:293786	4/25 (16%)
		ANK repeat	777..806	CDD:293786	9/46 (20%)
		ANK repeat	808..839	CDD:293786	7/37 (19%)
		ANK repeat	841..873	CDD:293786	6/45 (13%)
		ANK repeat	875..906	CDD:293786	6/30 (20%)
		ANK repeat	908..939	CDD:293786	5/30 (17%)
		ANK repeat	941..972	CDD:293786	8/34 (24%)
		SET_EHMT1	1039..1269	CDD:380933	92/337 (27%)