Protein Alignment egg and setbp1

DIOPT Version :10

• Sequence 1: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: XP_005165732.2
• Gene: setbp1 / 796785
• ZFINID: ZDB-GENE-060526-72
• Length: 1438
• Species: Danio rerio
• Alignment Length: 1355
• Identity: 255/1355 - (18%)
• Similarity: 419/1355 - (30%)
• Gaps: 523/1355 - (38%)

  Fly    22 QETPASREKSYGLPVR---KGEN-SLESPAEQAAKDVEIEELTHSEAIAATG------------S 70
            :|....|:::|..|.:   |.|| .:|:...:.:|..:|..|..::.:...|            .
Zfish   149 EEKGPPRKRTYERPSKLLGKTENVMMENTKPKQSKSNDILHLDWTKKLDTVGEVGSQEQNRTEPE 213

  Fly    71 TRKQCPYGGKAP-DEPG---------KLADESEDRKGENTKAIASSP---VLVAVDSDSSVELIE 122
            |:|:.....|.| .||.         |:||   ...|.:..:..|||   :|.|    |||..:.
Zfish   214 TKKESACTNKGPLPEPSTPFLKTQVKKVAD---GLSGSHFGSAMSSPSTDLLAA----SSVNTVM 271

  Fly   123 SPVKFSS----------------------ANESEKDPPKPDAVNEAAAKEAEEM-TDSSISSPTS 164
            ||...||                      .....|||.|...::....:..::| .|:.......
Zfish   272 SPSTDSSLFSFNKDRGLQQVTEQVFGNIKRKYGRKDPTKTPVMHNLDLQWVKKMDRDTENQDSAK 336

  Fly   165 ESFPEKDEKTNKENEQEPPGMEVDQD-----------VEESISRP------------------AE 200
            |..|...:|...|.|.|.|...:|.|           .|||.|:.                  .:
Zfish   337 EKQPYSQDKCAFEEEPEKPINRLDDDNKTTTGCGTHYTEESRSKKRRNRKVTEDSMVSNAQTVQQ 401

  Fly   201 EYKIENTLKGHKRISLTEIEEHKIVDKKDDVLEVELEKGTAPK-------AAEDEKLNALLSDGD 258
            :.|.:||.:|..::.:|         ||.||        .|||       .::::....:..|.:
Zfish   402 DEKTDNTDQGCTKLKVT---------KKTDV--------NAPKQFGFNLQQSQEDIAGTVTDDAE 449

  Fly   259 VF-----------------YDKEC-------------VNCNCTKLHKQ----------------- 276
            :|                 .||:.             :....:..||.
Zfish   450 MFQNRPRKTPAGRARSMIDVDKQTEGRQSKVKDRWLYLKSQNSSPHKDLNQSLSIEEPPSAFPIT 514

  Fly   277 -----YVLANMATLNFYQVLRKSSKQQFLCMGCHDTAMDLYEEYAGQLMAKQPLL-LKDFHQDHA 335
                 |...|..|: ...|.:|..:.:                       ||||| ::..|:..|
Zfish   515 PSSPLYTNTNSLTV-ITPVKKKRGRPK-----------------------KQPLLTVETIHEGTA 555

  Fly   336 DF----VALDSSDEEEEEK--------------------QPEKSD------------FSKNKLQL 364
            ..    :|.|||:..:.:|                    |.:|||            ..:.|:|.
Zfish   556 TSPVSPIAHDSSNTSKRKKHNMSKLVQLAFHKSPPAQQLQLKKSDQEGVLKKRTPTKIKEVKMQN 620

  Fly   365 IEDEL-------------DDAIKNVLNKVDFTAQLSWSKTILQAKADHL-----ERQFALADVEL 411
            |.:||             :..:.|.::.|..|.:..:.|.|..:|...:     ..:...||:..
Zfish   621 IINELLSTSSSGNLAPKPNVPVSNAMSTVASTIEARFGKQINVSKRGTIYIGKKRGRKPRADLSS 685

  Fly   412 EKVQTTADKMHCALYNSCPVAHKHLPTLDIE----PSDYV------HEVPPPGEIVRPPIQLGET 466
            ::.:..|...| .|.||.|..:..:|:.:..    ||..|      |..  ||.... |:....:
Zfish   686 QQDEHKASDNH-LLLNSSPFENPLVPSSNSSTTGMPSPRVMHSFSSHSA--PGGAAH-PVTTDTS 746

  Fly   467 YYAVKNKAIASWVSIKVIEFTESTAINGNTMKSYKIR----YLNTPYQM-----IKTVTAKHIAY 522
            .:.:|     :..:::.|....:....|....::|:.    ..|:|..:     ||.||...::.
Zfish   747 QHDLK-----TMPNLQPISALPTKTHKGLLSSNWKLSPPRLMANSPSHLSEVASIKEVTLSPVSE 806

  Fly   523 F---EPPPVRLTIGTRVIAYFDGTTLSRGKDKGVVQSAFYPGIIAEPLKQANRYRY---LIFYDD 581
            .   |..|....|||      |..:.|...:||                .|:|.||   |..:|
Zfish   807 SHSEETIPSDSGIGT------DNNSTSDQTEKG----------------PASRRRYSFDLCSFD- 848

  Fly   582 GYTQYVPHRDVRLVCQASEKVWEDVHA-ASRDFIQKYVEKYSVDRPMVQCTRGQSMTTESNGTWL 645
                            |:|....|..: |:|...||:|...||:....|    :::..:.:....
Zfish   849 ----------------ATEAAVIDAKSKAARGHYQKHVTAVSVENFFAQ----ENLKKQKHRRKR 893

  Fly   646 YARVIDIDCSLVLMQFEGD------------------KNHTEWIYRGSLRLG-------PVF--- 682
            .|.....|     :||..|                  |.:.|..|....||.       |.:
Zfish   894 KALQSQDD-----LQFMADLEELVSKFQVFRISHRNYKFYHENSYPSIFRLNFDHYYPMPYYPYD 953

  Fly   683 --RETQNNMNSSSAQQLRVPRRTE-----PFIR------------------YTKEMESSSKVNQQ 722
              ...:.:.:.|..::.|..:..|     |||:                  ||....::|.:|
Zfish   954 PLHYLRRSSDKSKRRRGRPAKSDEPISKMPFIQGFGCPVPGGNYYAPYAMPYTSMPLATSMIN-- 1016

  Fly   723 MRAFARKSSASAQNNALAAASS--AATPAGGRTNAGGVSTSNSASAVRHLNNSTIYVDDENRPKG 785
            |..:.:..|....::||...:|  ...|........|.|:..|||: ||
Zfish  1017 MGYYGQYPSPLYLSHALGPTASPLMRPPVPPPKFHPGASSCLSASS-RH---------------- 1064

  Fly   786 HVVYFTAKRNLP-----PKMYKCHECSPNCL-----------FKIVHRLDSY------------- 821
                  ..:|:|     .:|...|..|.:||           .|..|:.|.|
Zfish  1065 ------RVKNMPHEMSSSRMSDSHHPSSSCLGSVCLHKRKHKHKYKHKEDQYIQEREDLGGLFSG 1123

  Fly   822 --SPLAKPLLSGWERLVMRQKTKKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDFTPDLK 884
              ||....||:  |||   :|...|.:.....||.....:.     :|:.|...||.
Zfish  1124 TQSPAFLSLLN--ERL---EKNSLSKLKDKQRGKHSTDTSP-----KASRNYFEVDT-------- 1170

  Fly   885 CLAEYSIDPSIVKDTDISKGQEKMAIPLVNYYDNTLPPPCT-------YAKQRIPTE---GVHLN 939
             |:..|:..|  :....::|:      .:|.:.|.    ||       .|.|..|.:   |.||.
Zfish  1171 -LSSLSLSDS--QHCKRTRGE------TLNNFLNI----CTRQPHERLRASQDQPLDLFKGQHLG 1222

  Fly   940 LD-----------EEFLLCCDCE----DDCSDKSKCACWQLTVAGVR---YCNPKKPIEEIGYQY 986
            .|           |:|....:..    ..||::.....:|.:.|...   |....|.:||:
Zfish  1223 GDDSSIHIRRHSLEDFTTYKEGSMASFQGCSEERAEQMYQCSTAVAEPSSYKRRSKLVEEV---- 1283

  Fly   987 KRLHEHVPTGIYECNSRCKC--------KKNC--LNRVVQFSLEMKLQ-VFKTSN 1030
                |.|     :|:.|.||        |||.  :|::::..   :|| ..||.|
Zfish  1284 ----EEV-----QCDMRKKCAFSKILTTKKNLDHVNKILKVK---RLQRQAKTGN 1326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	Tudor_SETDB1_rpt1	532..622	CDD:410453	21/93 (23%)
		Tudor_SETDB1_rpt2	630..684	CDD:410548	11/83 (13%)
		HMT_MBD	823..879	CDD:238689	14/55 (25%)
		SET_SETDB1	900..1262	CDD:380915	37/170 (22%)
setbp1	XP_005165732.2	None