DRSC/TRiP Functional Genomics Resources

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Protein Alignment egg and Kmt2b

DIOPT Version :9

Sequence 1:NP_611966.3 Gene:egg / 37962 FlyBaseID:FBgn0086908 Length:1262 Species:Drosophila melanogaster
Sequence 2:NP_001277502.1 Gene:Kmt2b / 75410 MGIID:109565 Length:2722 Species:Mus musculus


Alignment Length:125 Identity:39/125 - (31%)
Similarity:53/125 - (42%) Gaps:29/125 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  1156 NADLDETVRENS---VRRLF---------GKDEAPY--------IMDAKTTGNLGRYFNHSCSPN 1200
            |.|..|.|.|.|   :|.:.         ||....|        ::||...||..|:.||||.||
Mouse  2601 NIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPN 2665

  Fly  1201 LFVQNVFVD--THDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCR 1258
            .|.:.:.|:  .|      :..|:...|..|.|||::|.:.:.....| |.|.|||..||
Mouse  2666 CFSRVIHVEGQKH------IVIFALRRILRGEELTYDYKFPIEDASNK-LPCNCGAKRCR 2718

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
eggNP_611966.3 HMT_MBD 823..879 CDD:238689
Pre-SET 901..1013 CDD:282838
SET 1022..1239 CDD:214614 31/104 (30%)
Kmt2bNP_001277502.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..65
Menin-binding motif (MBM). /evidence=ECO:0000250|UniProtKB:Q9UMN6 17..36
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 82..524
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..783
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 831..872
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 899..964
zf-CXXC 963..1010 CDD:251032
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1032..1076
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1088..1138
PHD1_KMT2B 1209..1255 CDD:277064
PHD2_KMT2B 1257..1306 CDD:277066
PHD3_KMT2B 1343..1399 CDD:277068
Bromo_ALL-1 1380..1522 CDD:99925
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1550..1572
ePHD_KMT2B 1587..1691 CDD:277164
FYRN 1740..1786 CDD:283589
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2065..2113
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2125..2169
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2288..2365
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2391..2417
FYRC 2420..2504 CDD:197781
WDR5 interaction motif (WIN). /evidence=ECO:0000250|UniProtKB:Q9UMN6 2515..2520
SET <2566..2722 CDD:225491 39/125 (31%)
SET 2584..2704 CDD:214614 31/108 (29%)