Protein Alignment egg and Nsd2

DIOPT Version :9

• Sequence 1: NP_611966.3
• Gene: egg / 37962
• FlyBaseID: FBgn0086908
• Length: 1262
• Species: Drosophila melanogaster
• Sequence 2: NP_001178481.2
• Gene: Nsd2 / 680537
• RGDID: 1307955
• Length: 1365
• Species: Rattus norvegicus
• Alignment Length: 1559
• Identity: 295/1559 - (18%)
• Similarity: 463/1559 - (29%)
• Gaps: 685/1559 - (43%)

  Fly     8 VDCL------ESSGSTVEDVQETPASREKSYGLPVRKGENSLES---------------PAEQAA 51
            |.|:      |..||.....|....:.|.|..|...:..|||:.               |||
  Rat    16 VKCMKMKQAPEILGSANGKTQNCEVNHECSVFLSKAQLSNSLQEGVMQKFNGHDALPFLPAE--- 77

  Fly    52 KDVEIEELTHSEAIAATGSTRKQCPYGGKAPDEPG----KLADESEDRKGENTKAIASSPVLVAV 112
               ::::||             .|.:.|    |||    ||..|:::.||     |.:.|....:
  Rat    78 ---KLKDLT-------------SCVFNG----EPGAHDTKLCFETQEVKG-----IGTPPNTTPI 117

  Fly   113 DSDSSVELIESPVKFSSANESEKDPPKPDAVNEAAAKEAEEMTDSSISSPTSESFPEKDEKTNKE 177
            .:.|.    |..:|.:....:.|...:.....:.||    :|:.|      .|:..:.|.||.:.
  Rat   118 KNGSP----EIKLKITKTYMNGKPLFESSICGDGAA----DMSQS------EENGQKSDNKTRRN 168

  Fly   178 NEQEPPGMEVDQDVEESISRPAEEYKIENTLKGHKRISLTEIEEHKIVDKKDDVLEVELEKGTAP 242
            .::   .::.|..:|:.:...|...||.:.            |:.||..||:          :.|
  Rat   169 RKR---SIKYDSLLEQGLVEAALVSKISSP------------EDKKIPVKKE----------SCP 208

  Fly   243 KAAEDEKLNALLSDGDVFYDK-------ECVNC------NCTKLHKQYVLANMATLNFYQVLRKS 294
            .:..|..|....:.||:.:.|       .|:..      |.|||..|               :||
  Rat   209 NSGRDRDLLLKYNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQ---------------KKS 258

  Fly   295 SKQQFLCMGCHDTAMDLYEEYAGQLMAKQPLLLKDFHQDHADFVALDSSDE-----EEEEKQ-PE 353
            ::|                 |..|.....|.....|.:   ..||.:..::     :|..|| |.
  Rat   259 ARQ-----------------YHVQFFGDAPERAWIFEK---SLVAFEGEEQFEKLCQESAKQAPT 303

  Fly   354 KSDFSKNKLQLIEDELDDAIKNVLNKVDFTAQLSWSKTILQAKADHLERQFALADVELEKVQTTA 418
            |::    |::|            |..:....:..|...|:||:      :.|...||..|.:.|
  Rat   304 KAE----KIKL------------LKPISGRLRAQWEMGIVQAE------EAASMSVEERKAKFT- 345

  Fly   419 DKMHCALYNSCPVAHKHLPTLDIEPSDYVHEVPPPGEIVRPPIQLGETYYAVKNKAIASWVSIKV 483
                 .||..        ..|.:.|     :|.....|...|  |||    :.:.::|:
  Rat   346 -----FLYVG--------DQLRLNP-----QVAKEAGIATEP--LGE----MVDSSVAN------ 380

  Fly   484 IEFTESTAINGNTMKSYKIRYLNTPYQMIKTVTAKHIAYFEPPPVRLTIGTRVIAYFDGTTLSRG 548
                |..|::..||:.                        |..||:    .|..|....:..::.
  Rat   381 ----EEAAVDPGTMRE------------------------EDIPVK----RRRRAKRSSSAENQE 413

  Fly   549 KDKGVVQSAFYPGIIAEPLK-------------QANRYR-------YLIFYDDGYTQYVPHRDVR 593
            .|.|..:|.......|||.:             .|:|.|       :|:|..       .||| .
  Rat   414 GDPGTEKSTPPKMADAEPKRGVGSPAGRKRSTGSASRSRKGDSAAQFLVFCQ-------KHRD-E 470

  Fly   594 LVCQ---ASEKVWEDVHAASRDFIQ-----KYVEKYSVDRPMVQC--------TRGQSMTTESNG 642
            :|.:   |||:..|::..:....:.     :|..|:|:   |:..        |.|:. .|.:..
  Rat   471 VVAEHPDASEEEIEELLGSQWSMLNEKQKARYNTKFSL---MISAQSEEDSGNTSGKK-RTHTKR 531

  Fly   643 TWLYARVIDIDCSLVLMQFEGDKNHTEWIYRGSLRLGPVFRETQNNMNSSSAQQLRVPRRTEPFI 707
            |......:|:: .....:...||:        |||.    |||..:..:          ||..:
  Rat   532 TDDPPEDVDVE-DAPRKRLRTDKH--------SLRK----RETITDKTA----------RTSSY- 572

  Fly   708 RYTKEMESSSKVNQQMRAFARKSSASA------QNNALAAASSAATPAGGRTNAGGVSTSNSASA 766
               |.:|::|.:..|.   |.|:.:.|      :|.|.|.||||.          |.:.|:|.||
  Rat   573 ---KAIEAASSLKSQA---ATKNLSDACKPLKKRNRASATASSAL----------GFNKSSSPSA 621

  Fly   767 VRHLN-----------NSTIYVDDENRPKGHVVYFTAKRNLPPKM-YKCHECSPNCLFKIVHRLD 819
            ....|           .|.....||.:.:..|....::|.:..|. |.|..|
  Rat   622 SLTENEVSDNPGDEPSESPYESADETQTEASVSSKKSERGMAAKKEYVCQLC------------- 673

  Fly   820 SYSPLAKPLLSGWERLVMRQKTKKSVVYKGPC---------GKSLR---------SLAEVHRYLR 866
                               :||...::.:|||         |.|.|         ..:.:|....
  Rat   674 -------------------EKTGSLLLCEGPCCGAFHLACLGLSQRPEGRFTCTECASGIHSCFV 719

  Fly   867 ATENVLN-----------------VDNFDFT---------PDLKCLAEYSIDPSIVKDTDISKGQ 905
            ..|:.:.                 |..:..|         |...|::.::.:||..:.   |||:
  Rat   720 CKESKMEVKRCMVNQCGKFYHEACVKKYPLTVFESRGFRCPLHSCMSCHASNPSNPRP---SKGK 781

  Fly   906 EKMAIPL-VNYY--DNTLPPPCT-YAKQRIPTEG-----------VHLNLDEEF-------LLCC 948
            ....:.. |.|:  |..|...|: .|...|...|           .|:|:...|       ||||
  Rat   782 MMRCVRCPVAYHGGDACLAAGCSVIASNSIICTGHFTARKGKRHHTHVNVSWCFVCSKGGSLLCC 846

  Fly   949 ---------DCE-----------DDCSDKSKC----ACWQLTVAGVRY-----CNPK-------K 977
                     ||.           :||....|.    ..| :.:...|:     |:||       |
  Rat   847 EACPAAFHPDCLSIEMPDGSWFCNDCRAGKKLHFQDIIW-VKLGNYRWWPAEVCHPKNVPPNIQK 910

  Fly   978 PIEEIG-------------------------------YQ-------------------------- 985
            ...|||                               ||
  Rat   911 MKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNALQEAEARFNEIKLQ 975

  Fly   986 ---------------YKRLHEHVPTG---IYECN----SRCKCK----------KNCLNRVVQFS 1018
                           ||.:..:.|.|   ||..:    .:|.||          ..||||::.|.
  Rat   976 REARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGSDSECLNRMLMFE 1040

  Fly  1019 LEMKL--------------------QVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEG 1063
            ...::                    ::.||..:||||....||.||.|:..|.|.|:.|.
  Rat  1041 CHPQVCPAGEYCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEE----- 1100

  Fly  1064 GQDAGDEYFADLDYIEVAEQLKEGYESEVDHSDPDAEEDNGGPDAEDDDDFRPNYHYQRKIKRSS 1128
                           |...::|..:|:::.|                        .|...|
  Rat  1101 ---------------ECMARIKYAHENDITH------------------------FYMLTI---- 1122

  Fly  1129 RSGSTQNSSTQSSELDSQERAVINFNPNADLDETVRENSVRRLFGKDEAPYIMDAKTTGNLGRYF 1193
                                                        .||.   |:||...||..|:.
  Rat  1123 --------------------------------------------DKDR---IIDAGPKGNYSRFM 1140

  Fly  1194 NHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNC 1257
            ||||.||.......|: .|.|   |..|:...|.:|||||:|||.:  .:..:...|:|||.||
  Rat  1141 NHSCQPNCETLKWTVN-GDTR---VGLFAVCDIPAGTELTFNYNLD--CLGNEKTVCRCGASNC 1198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
egg	NP_611966.3	HMT_MBD	823..879	CDD:238689	11/90 (12%)
		Pre-SET	901..1013	CDD:282838	45/258 (17%)
		SET	1022..1239	CDD:214614	49/236 (21%)
Nsd2	NP_001178481.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351972
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930